Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels
Fouda MA, Ghovanloo M, Ruben PC. Cannabidiol protects against high glucose‐induced oxidative stress and cytotoxicity in cardiac voltage‐gated sodium channels. British Journal Of Pharmacology 2020, 177: 2932-2946. PMID: 32077098, PMCID: PMC7279989, DOI: 10.1111/bph.15020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCannabidiolCricetinaeCricetulusGlucoseHumansOxidative StressVoltage-Gated Sodium ChannelsConceptsHigh glucoseOxidative stressHigh glucose-induced oxidative stressCardiac voltage-gated sodium channelGlucose-induced oxidative stressReactive oxygen speciesCardiac sodium channel isoformChannel inhibitory effectVoltage-gated sodium channelsSteady-state fast inactivationHigh glucose conditionsSodium channel isoformsAction potential modellingDeleterious effectsCardiovascular complicationsDiabetic patientsAction potentialsCell viability assaysArrhythmiasMajor causeInhibitory effectChannel isoformsCannabidiolGlucose conditionsSodium channels