2015
The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome
Tal R, Seifer DB, Arici A. The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome. Seminars In Reproductive Medicine 2015, 33: 195-207. PMID: 26036901, DOI: 10.1055/s-0035-1552582.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeGrowth factorOvarian syndromePathophysiology of PCOSAngiogenic factor imbalanceOvarian hyperstimulation syndromeCommon endocrine disorderVascular endothelial growth factorPlatelet-derived growth factorBasic fibroblast growth factorMultiple angiogenic factorsEndothelial growth factorFibroblast growth factorHyperstimulation syndromeOvulatory dysfunctionStromal vascularityAnovulatory infertilityPolycystic ovariesEndocrine disordersReproductive ageTreatment strategiesFollicular growthOvarian angiogenesisAngiogenic factorsCorpus luteum
2013
The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy
Tal R, Segars JH. The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy. Human Reproduction Update 2013, 20: 194-216. PMID: 24077979, PMCID: PMC3922145, DOI: 10.1093/humupd/dmt042.Peer-Reviewed Original ResearchConceptsUterine artery embolizationEpidermal growth factorAbnormal vasculatureAngiogenic growth factorsGrowth factorUterine fibroidsAnti-angiogenic treatment strategiesVascular endothelial growth factorPlatelet-derived growth factorBasic fibroblast growth factorEndothelial growth factorAnti-angiogenic mechanismGrowth factor dysregulationFibroblast growth factorArtery embolizationGnRH agonistTreatment strategiesBenign tumorsMultiple growth factorsCommon treatmentFibroid growthFuture therapiesReduced vascularizationVascular supplyLeiomyoma tissue