2018
The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis
Wu X, Ren G, Zhou R, Ge J, Chen F. The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis. Laboratory Investigation 2018, 99: 499-513. PMID: 30487596, DOI: 10.1038/s41374-018-0135-3.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channelsChondrocyte pyroptosisCaspase-1Rheumatoid arthritisIL-18Role of Ca2Autoimmune diseasesIL-1βAdjuvant arthritis rat modelExpression of ASIC1aMain pathogenic featureRat adjuvant arthritisJoints of ratsArthritis rat modelApoptosis-associated speck-like proteinProinflammatory cytokines interleukinExpression of COL2ASpeck-like proteinASIC-1asAdjuvant arthritisPoor prognosisCytokines interleukinNLRP3 inflammasomeAA ratsRat model
2017
Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes
Xie Y, Li Y, Zhou R, Dai B, Qian Y, Wu X, Ge J, Hu W, Chen F. Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes. Molecular And Cellular Biochemistry 2017, 443: 181-191. PMID: 29273849, DOI: 10.1007/s11010-017-3223-6.Peer-Reviewed Original ResearchConceptsRat articular chondrocytesRheumatoid arthritisEffect of autophagyPathogenesis of RAArticular chondrocytesProgression of RAInhibition of ASIC1aAcid-sensing ion channel 1aMultiple pathogenic factorsDegenerative joint diseaseArticular chondrocyte apoptosisRat knee jointsIon channel 1aShort hairpin RNAPrecise etiologyJoint diseasePathogenic factorsKnee jointPsalmotoxin-1Chondrocyte apoptosisPrimary articular chondrocytesChannel 1aASIC1aAutophagy fluxBeclin-1