Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway
Ma G, Yang Y, Chen Y, Wei X, Ding J, Zhou R, Hu W. Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway. Frontiers In Pharmacology 2021, 12: 655551. PMID: 33927631, PMCID: PMC8076952, DOI: 10.3389/fphar.2021.655551.Peer-Reviewed Original ResearchArticular cartilage damageAdjuvant arthritisChondrocyte apoptosisCartilage damageIL-6Rat modelMMP-13Adjuvant arthritis rat modelRat adjuvant arthritisArthritis rat modelMajor pathological featureADAMTS-5 expressionBcl-2/Bax ratioIndian hedgehogArticular cartilage injuryTransient receptor potential melastatinBcl-2/Arthritis scoreRheumatoid arthritisPathological featuresChondrocyte injuryAA ratsADAMTS-5Articular diseaseClinical signs