2023
Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics
Ouyang Z, Dong L, Yao F, Wang K, Chen Y, Li S, Zhou R, Zhao Y, Hu W. Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics. International Journal Of Molecular Sciences 2023, 24: 9841. PMID: 37372989, PMCID: PMC10298547, DOI: 10.3390/ijms24129841.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisArticular cartilageCourse of osteoarthritisNew biochemical markersDisease progressionPathogenic factorsCartilage damageDegradation of collagenBiochemical markersProgressive destructionClinical diagnosisMechanical injuryConnective tissueDisease statesRole of collagenCollagen productionLow immunogenicityFacilitate drug developmentArthritisDrug developmentOsteoarthritisBiomechanical propertiesMechanical functionCartilageCollagen
2022
Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities
Liang H, Yin H, Li S, Chen Y, Zhao Y, Hu W, Zhou R. Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities. Biomolecules 2022, 12: 1383. PMID: 36291594, PMCID: PMC9599458, DOI: 10.3390/biom12101383.Peer-Reviewed Original ResearchConceptsPathogenesis of RARheumatoid arthritisCalcium-permeable channelsIntra-articular inflammationCommon autoimmune diseaseTreatment of RAEntry of CaDrug targetsSynovial invasionPatients' qualityAutoimmune diseasesNovel drug targetsCartilage damageArthritisTherapeutic opportunitiesPathological processesCalcium signalingInflammationPathogenesisSpecific roleRAHuman cellsTargetCell membraneDisease
2021
Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis
Wei X, Fu W, Zhou R, Chen Y, Lu C, Hu W. Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis. Naunyn-Schmiedeberg's Archives Of Pharmacology 2021, 394: 1285-1299. PMID: 33527195, DOI: 10.1007/s00210-021-02048-8.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisTreatment of RAActive rheumatoid arthritisDisease target networkChinese traditional patent medicineTraditional Chinese medicineRA diseaseMolecular mechanismsImmune responsePharmacological effectsPrecise molecular mechanismsClinical practiceSystemic pharmacologyPharmacological investigationsElimination parametersChinese medicinePatent medicinePotential mechanismsDirect targetArthritisTreatmentCandidate compoundsTotalCapsuleProtein-protein interaction network
2019
Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats
Zhou R, Zhu F, Wu X, Song S, Chen Y, Zhu C, Dai B, Qian X, Wang K, Hu W, Chen F. Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats. Journal Of Cellular And Molecular Medicine 2019, 23: 7879-7884. PMID: 31508906, PMCID: PMC6815768, DOI: 10.1111/jcmm.14629.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisEffect of autophagyChondrocyte apoptosisAdjuvant arthritisDevelopment of RATreatment of RASystemic autoimmune diseaseAdjuvant arthritis ratsArticular chondrocyte apoptosisAutophagy activator rapamycinArticular cartilage injuryArticular chondrocytesRat articular cartilageArthritis ratsJoint deformityAutoimmune diseasesAA ratsCartilage injuryJoint functionChondrocyte autophagyAutophagy inhibitorPotential targetArthritisApoptosisRats
2016
Functions of interleukin‐34 and its emerging association with rheumatoid arthritis
Zhou R, Wu X, Xie Y, Dai B, Hu W, Ge J, Chen F. Functions of interleukin‐34 and its emerging association with rheumatoid arthritis. Immunology 2016, 149: 362-373. PMID: 27550090, PMCID: PMC5095491, DOI: 10.1111/imm.12660.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisIL-34Inflammatory arthritisAutoimmune diseasesDevelopment of RAInterleukin-34Active rheumatoid arthritisSystemic autoimmune diseaseEffective treatment optionExtra-articular lesionsNovel therapeutic strategiesMononuclear phagocyte lineage cellsSynovial inflammationTreatment optionsSpecific monoclonal antibodiesTherapeutic strategiesTherapeutic targetArthritisMonoclonal antibodiesExperimental modelLineage cellsMultiple jointsReceptor ligandsInflammationDisease