2021
Modeling the Cost-Effectiveness of Express Multisite Gonorrhea Screening Among Men Who Have Sex With Men in the United States
Earnest R, Rönn MM, Bellerose M, Menon-Johansson AS, Berruti AA, Chesson HW, Gift TL, Hsu KK, Testa C, Zhu L, Malyuta Y, Menzies NA, Salomon JA. Modeling the Cost-Effectiveness of Express Multisite Gonorrhea Screening Among Men Who Have Sex With Men in the United States. Sexually Transmitted Diseases 2021, 48: 805-812. PMID: 33993161, PMCID: PMC8505150, DOI: 10.1097/olq.0000000000001467.Peer-Reviewed Original ResearchConceptsGonococcal infectionAsymptomatic MSMAnatomic sitesUS MSMIncremental cost-effectiveness ratioMore anatomic sitesCost-effectiveness ratioExtragenital screeningGonorrhea ScreeningPhysical examinationSmall cost savingsAsymptomatic screeningProvider consultationRoutine screeningMore infectionsOnward transmissionVisit costsCumulative health effectsIntervention yearInfectionMSMHealth effectsDiagnostic costsCost-effective optionMenAsynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic
Petrone ME, Earnest R, Lourenço J, Kraemer MUG, Paulino-Ramirez R, Grubaugh ND, Tapia L. Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic. Nature Communications 2021, 12: 151. PMID: 33420058, PMCID: PMC7794562, DOI: 10.1038/s41467-020-20391-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAedesAnimalsChikungunya FeverChikungunya virusChildChild, PreschoolCommunicable Diseases, EmergingDengueDengue VirusDisease OutbreaksDominican RepublicEndemic DiseasesEpidemiological MonitoringFemaleHumansInfantInfant, NewbornMaleMosquito ControlMosquito VectorsSpatio-Temporal AnalysisYoung AdultZika VirusZika Virus InfectionConceptsDengue outbreakDisease outbreaksDengue fever casesOutbreak of chikungunyaMosquito-Borne VirusesFever casesFuture health crisesMosquito-borne disease outbreaksFuture outbreaksVirus transmissionAedes mosquitoesSustainable disease control measuresHealth crisisVirusDisease control measuresOutbreakChikungunyaConstant surveillanceZikaControl measuresDominican Republic
2020
Sex differences in immune responses that underlie COVID-19 disease outcomes
Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Casanovas-Massana A, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Shaw A, Fournier J, Odio C, Farhadian S, Dela Cruz C, Grubaugh N, Schulz W, Ring A, Ko A, Omer S, Iwasaki A. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature 2020, 588: 315-320. PMID: 32846427, PMCID: PMC7725931, DOI: 10.1038/s41586-020-2700-3.Peer-Reviewed Original ResearchConceptsInnate immune cytokinesFemale patientsMale patientsImmune cytokinesDisease outcomeImmune responseCOVID-19COVID-19 disease outcomesPoor T cell responsesSARS-CoV-2 infectionSevere acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusSex-based approachModerate COVID-19Sex differencesRobust T cell activationT cell responsesWorse disease progressionWorse disease outcomesHigher plasma levelsNon-classical monocytesCoronavirus disease 2019T cell activationImmunomodulatory medicationsPlasma cytokinesLongitudinal analyses reveal immunological misfiring in severe COVID-19
Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A, Herbst R, Shaw A, Medzhitov R, Schulz W, Grubaugh N, Dela Cruz C, Farhadian S, Ko A, Omer S, Iwasaki A. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature 2020, 584: 463-469. PMID: 32717743, PMCID: PMC7477538, DOI: 10.1038/s41586-020-2588-y.Peer-Reviewed Original ResearchConceptsSevere COVID-19Moderate COVID-19Immune signaturesDisease outcomeCOVID-19Disease trajectoriesInterleukin-5Early immune signaturesInnate cell lineagesType 2 effectorsT cell numbersPoor clinical outcomeWorse disease outcomesImmune response profileCoronavirus disease 2019Distinct disease trajectoriesCytokine levelsImmunological correlatesImmune profileClinical outcomesEarly elevationImmune profilingIL-13Immunoglobulin EDisease 2019Population-level Benefits of Extragenital Gonorrhea Screening Among Men Who Have Sex With Men: An Exploratory Modeling Analysis.
Earnest R, Rönn M, Bellerose M, Gift T, Berruti A, Hsu K, Testa C, Zhu L, Malyuta Y, Menzies N, Salomon J. Population-level Benefits of Extragenital Gonorrhea Screening Among Men Who Have Sex With Men: An Exploratory Modeling Analysis. Sexually Transmitted Diseases 2020, 47: 484-490. PMID: 32355108, PMCID: PMC7903327, DOI: 10.1097/olq.0000000000001189.Peer-Reviewed Original ResearchConceptsExtragenital screeningMultisite infectionExtragenital sitesRectal screeningSite-specific prevalenceGonorrhea ScreeningPharyngeal sitesGonorrhea infectionExtragenital infectionsGonorrhea prevalencePopulation-level benefitsRectal sitesImproved screeningDisease controlInfectionPrevalenceIncidenceMenHigh rateSexScreeningRace groupsScreening levelsGonorrheaClinic
2019
The Potential Population-Level Impact of Different Gonorrhea Screening Strategies in Baltimore and San Francisco: An Exploratory Mathematical Modeling Analysis
Rönn M, Testa C, Tuite A, Chesson H, Gift T, Schumacher C, Williford S, Zhu L, Bellerose M, Earnest R, Malyuta Y, Hsu K, Salomon J, Menzies N. The Potential Population-Level Impact of Different Gonorrhea Screening Strategies in Baltimore and San Francisco: An Exploratory Mathematical Modeling Analysis. Sexually Transmitted Diseases 2019, 47: 143-150. PMID: 31842089, PMCID: PMC7012354, DOI: 10.1097/olq.0000000000001108.Peer-Reviewed Original ResearchConceptsAnnual screeningMost infectionsHigh-burden areasAdditional screening testFocused intervention strategiesCompartmental transmission modelRace/ethnicityPotential population-level impactCare cascadeBurden areasAcquisition riskScreen populationsScreening testPopulation-level impactInfectionSan FranciscoSurveillance dataPrevalence distributionScreening strategyInterventionIntervention strategiesSuch interventionsGonorrheaTime trendsMathematical modeling analysis