PmpG303-311, a Protective Vaccine Epitope That Elicits Persistent Cellular Immune Responses in Chlamydia muridarum-Immune Mice
Johnson RM, Yu H, Kerr MS, Slaven JE, Karunakaran KP, Brunham RC. PmpG303-311, a Protective Vaccine Epitope That Elicits Persistent Cellular Immune Responses in Chlamydia muridarum-Immune Mice. Infection And Immunity 2012, 80: 2204-2211. PMID: 22431650, PMCID: PMC3370596, DOI: 10.1128/iai.06339-11.Peer-Reviewed Original ResearchConceptsGenital tract infectionAntigen-presenting cellsT cell clonesTract infectionsMonths postinfectionImmune responseChlamydia muridarum Genital Tract InfectionProtective CD4 T cell responsesVaccine developmentPrimary genital tract infectionTh1 T cell clonesCD4 T cell responsesCD4 T-cell clonesSplenic antigen-presenting cellsAntigen-presenting cell populationsCell clonesCD4 T cellsT cell responsesCellular immune responsesProtective immune responsePromising vaccine candidateImmune C57BL/6 miceInfected epithelial cellsIrradiated splenocytesUrogenital chlamydia