Persistent TTX-Resistant Na+ Current Affects Resting Potential and Response to Depolarization in Simulated Spinal Sensory Neurons
Herzog RI, Cummins TR, Waxman SG. Persistent TTX-Resistant Na+ Current Affects Resting Potential and Response to Depolarization in Simulated Spinal Sensory Neurons. Journal Of Neurophysiology 2001, 86: 1351-1364. PMID: 11535682, DOI: 10.1152/jn.2001.86.3.1351.Peer-Reviewed Original ResearchConceptsPersistent TTX-R currentTTX-R currentsSmall DRG neuronsSodium currentDRG neuronsSmall dorsal root ganglion neuronsTTX-resistant sodium currentsDorsal root ganglion neuronsVoltage-gated sodium currentTetrodotoxin-sensitive sodium currentTTX-S currentsSpinal sensory neuronsGanglion neuronsNeuronal excitabilitySensory neuronsAction potentialsNeuronsSubthreshold stimuliDepolarizing phaseSpike electrogenesisAnode break excitationElectrogenic propertiesBreak excitationPossible contributionInactivation gateNav1.3 Sodium Channels: Rapid Repriming and Slow Closed-State Inactivation Display Quantitative Differences after Expression in a Mammalian Cell Line and in Spinal Sensory Neurons
Cummins TR, Aglieco F, Renganathan M, Herzog RI, Dib-Hajj SD, Waxman SG. Nav1.3 Sodium Channels: Rapid Repriming and Slow Closed-State Inactivation Display Quantitative Differences after Expression in a Mammalian Cell Line and in Spinal Sensory Neurons. Journal Of Neuroscience 2001, 21: 5952-5961. PMID: 11487618, PMCID: PMC6763143, DOI: 10.1523/jneurosci.21-16-05952.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxotomyBiolisticsCells, CulturedGanglia, SpinalGene ExpressionGenes, ReporterHumansIon Channel GatingKidneyMaleMembrane PotentialsMutagenesis, Site-DirectedNeurons, AfferentPatch-Clamp TechniquesPolymerase Chain ReactionProtein SubunitsRatsReaction TimeSodiumSodium ChannelsSpinal CordTetrodotoxinConceptsNav1.3 channelsRapid reprimingHEK-293 cellsDRG neuronsTTX-sensitive sodium currentDorsal root ganglion neuronsNav1.3 sodium channelsSodium channelsSpinal sensory neuronsVoltage-gated sodium channelsSteady-state inactivationLarger ramp currentsHuman embryonic kidney 293 cellsPeripheral axotomyEmbryonic kidney 293 cellsGanglion neuronsSlow depolarizationSensory neuronsVoltage-dependent propertiesKidney 293 cellsSodium currentRamp currentsNav1.3NeuronsBeta2 subunit