2017
Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex
De Feyter H, Herzog RI, Steensma BR, Klomp DWJ, Brown PB, Mason GF, Rothman DL, de Graaf R. Selective proton‐observed, carbon‐edited (selPOCE) MRS method for measurement of glutamate and glutamine 13C‐labeling in the human frontal cortex. Magnetic Resonance In Medicine 2017, 80: 11-20. PMID: 29134686, PMCID: PMC5876108, DOI: 10.1002/mrm.27003.Peer-Reviewed Original Research
2009
Recurrent Antecedent Hypoglycemia Alters Neuronal Oxidative Metabolism In Vivo
Jiang L, Herzog RI, Mason GF, de Graaf RA, Rothman DL, Sherwin RS, Behar KL. Recurrent Antecedent Hypoglycemia Alters Neuronal Oxidative Metabolism In Vivo. Diabetes 2009, 58: 1266-1274. PMID: 19276443, PMCID: PMC2682668, DOI: 10.2337/db08-1664.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaAcute hypoglycemiaRecurrent hypoglycemiaEuglycemic conditionsGlucose utilizationRecurrent insulin-induced hypoglycemiaWhole-brain glucose metabolismNeuronal oxidative metabolismInsulin-induced hypoglycemiaHyperinsulinemic-hypoglycemic clampAntecedent hypoglycemiaPyruvate dehydrogenase fluxHigh glucose utilizationBrain metabolismRat modelHypoglycemiaGlucose metabolismHypoglycemic conditionsBrain metabolitesBrain functionTricarboxylic acid cycle activityOxidative metabolismEnergy substratesEuglycemiaInfusion
2003
Calmodulin Binds to the C Terminus of Sodium Channels Nav1.4 and Nav1.6 and Differentially Modulates Their Functional Properties
Herzog RI, Liu C, Waxman SG, Cummins TR. Calmodulin Binds to the C Terminus of Sodium Channels Nav1.4 and Nav1.6 and Differentially Modulates Their Functional Properties. Journal Of Neuroscience 2003, 23: 8261-8270. PMID: 12967988, PMCID: PMC6740705, DOI: 10.1523/jneurosci.23-23-08261.2003.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsSodium channelsNeuronal sodium channelsCalcium-independent mechanismVGSC isoformsNeuronal plasticityCell excitabilityNav1.6 channelsNav1.6Overexpression of CaMCalcium-dependent mannerCalcium-independent mannerNav1.4Sodium channel Nav1.4Channel Nav1.4Functional expressionCurrent amplitudeDistinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons
Herzog RI, Cummins TR, Ghassemi F, Dib-Hajj SD, Waxman SG. Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons. The Journal Of Physiology 2003, 551: 741-750. PMID: 12843211, PMCID: PMC2343279, DOI: 10.1113/jphysiol.2003.047357.Peer-Reviewed Original ResearchAnesthetics, LocalAnimalsCells, CulturedGanglia, SpinalIon Channel GatingKineticsMiceMice, Mutant StrainsNAV1.6 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelNAV1.8 Voltage-Gated Sodium ChannelNerve Tissue ProteinsNeurons, AfferentPatch-Clamp TechniquesRecombinant ProteinsSodium ChannelsTetrodotoxin