Featured Publications
Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine
Cotero V, Graf J, Miwa H, Hirschstein Z, Qanud K, Huerta TS, Tai N, Ding Y, Jimenez-Cowell K, Tomaio JN, Song W, Devarajan A, Tsaava T, Madhavan R, Wallace K, Loghin E, Morton C, Fan Y, Kao TJ, Akhtar K, Damaraju M, Barenboim L, Maietta T, Ashe J, Tracey KJ, Coleman TR, Di Carlo D, Shin D, Zanos S, Chavan SS, Herzog RI, Puleo C. Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine. Nature Biomedical Engineering 2022, 6: 683-705. PMID: 35361935, PMCID: PMC10127248, DOI: 10.1038/s41551-022-00870-w.Peer-Reviewed Original ResearchConceptsGlucose homeostasisGlucose toleranceNerve plexusAfferent autonomic nervesHyperinsulinemic euglycaemic clampNon-pharmacologic therapiesType 2 diabetesInsulin-resistant diabetesHepatic portal systemAutonomic nervesNerve pathwaysDiabetic miceFocused ultrasound stimulationPeripheral neuronsSensory projectionsIntestinal tissueMetabolic diseasesMulti-omics profilingPortal systemMetabolic tissuesGlucose availabilityDiabetesSelective activationPlexusUltrasound stimulation
2017
Nanopatterned Bulk Metallic Glass Biosensors
Kinser ER, Padmanabhan J, Yu R, Corona SL, Li J, Vaddiraju S, Legassey A, Loye A, Balestrini J, Solly DA, Schroers J, Taylor A, Papadimitrakopoulos F, Herzog RI, Kyriakides TR. Nanopatterned Bulk Metallic Glass Biosensors. ACS Sensors 2017, 2: 1779-1787. PMID: 29115132, DOI: 10.1021/acssensors.7b00455.Peer-Reviewed Original ResearchConceptsCyclic voltammetrySensitivity of biosensorsGlucose oxidase enzymeGlucose biosensor performanceBiocompatible biosensorSurface area enhancementBiosensor performanceElectrochemical measurementsElectrode sensitivityPt-BMGElectrode applicationsBiosensorOxidase enzymeVoltammetryBiocompatible materialsElectrodeΜA/Flat electrodesPlatinum-based bulk metallic glassArea enhancementControl electrodesBulk metallic glassOrders of magnitudeElectrical propertiesLow temperature
2013
Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain
2011
Insulin-Induced Hypoglycemia and Its Effect on the Brain Unraveling Metabolism by In Vivo Nuclear Magnetic Resonance
Herzog RI, Sherwin RS, Rothman DL. Insulin-Induced Hypoglycemia and Its Effect on the Brain Unraveling Metabolism by In Vivo Nuclear Magnetic Resonance. Diabetes 2011, 60: 1856-1858. PMID: 21709281, PMCID: PMC3121425, DOI: 10.2337/db11-0498.Peer-Reviewed Original Research
2009
Recurrent Antecedent Hypoglycemia Alters Neuronal Oxidative Metabolism In Vivo
Jiang L, Herzog RI, Mason GF, de Graaf RA, Rothman DL, Sherwin RS, Behar KL. Recurrent Antecedent Hypoglycemia Alters Neuronal Oxidative Metabolism In Vivo. Diabetes 2009, 58: 1266-1274. PMID: 19276443, PMCID: PMC2682668, DOI: 10.2337/db08-1664.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaAcute hypoglycemiaRecurrent hypoglycemiaEuglycemic conditionsGlucose utilizationRecurrent insulin-induced hypoglycemiaWhole-brain glucose metabolismNeuronal oxidative metabolismInsulin-induced hypoglycemiaHyperinsulinemic-hypoglycemic clampAntecedent hypoglycemiaPyruvate dehydrogenase fluxHigh glucose utilizationBrain metabolismRat modelHypoglycemiaGlucose metabolismHypoglycemic conditionsBrain metabolitesBrain functionTricarboxylic acid cycle activityOxidative metabolismEnergy substratesEuglycemiaInfusion