2023
MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis.
Park J, Hall C, Hubbard B, LaMoia T, Gaspar R, Nasiri A, Li F, Zhang H, Kim J, Haeusler R, Accili D, Shulman G, Yu H, Choi E. MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis. Diabetes 2023, 72: 1781-1794. PMID: 37725942, PMCID: PMC10658066, DOI: 10.2337/db23-0314.Peer-Reviewed Original ResearchConceptsIR endocytosisInsulin receptor endocytosisCell division regulatorsInsulin receptorProlongs insulin actionReceptor endocytosisTranscriptomic profilesInsulin stimulationEndocytosisMetabolic homeostasisCell surfaceGenetic ablationMetabolic functionsInsulin actionP31cometMad2BubR1DisruptionSignalingRegulatorHomeostasisAdipose tissueInteractionHepatic fat accumulationMetabolism
2021
An update on brown adipose tissue biology: a discussion of recent findings
Gaspar RC, Pauli JR, Shulman GI, Muñoz VR. An update on brown adipose tissue biology: a discussion of recent findings. AJP Endocrinology And Metabolism 2021, 320: e488-e495. PMID: 33459179, PMCID: PMC7988785, DOI: 10.1152/ajpendo.00310.2020.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT thermogenesisBrown adipose tissue biologyEnergy expenditureBrown-like cellsWhole-body glucoseAdipose tissue biologyBAT metabolismAdrenergic drugsAdipose tissuePotential treatmentThermogenic activityWhite adipocytesBody glucoseFat metabolismEndocrine mechanismsBeneficial roleSecretory moleculesActivity capacityTissue biologyThermogenesisRecent findingsRecent studiesAdditional focusMetabolism
2019
NAD+ precursor increases aerobic performance in mice
Crisol B, Veiga C, Braga R, Lenhare L, Baptista I, Gaspar R, Muñoz V, Cordeiro A, da Silva A, Cintra D, Moura L, Pauli J, Ropelle E. NAD+ precursor increases aerobic performance in mice. European Journal Of Nutrition 2019, 59: 2427-2437. PMID: 31494696, DOI: 10.1007/s00394-019-02089-z.Peer-Reviewed Original ResearchConceptsNR supplementationSkeletal muscleMitochondrial markersMitochondrial proteinsTranscriptomic analysisRate-limiting enzymePhysiological assaysMitochondrial metabolismMitochondrial biogenesisMitochondrial oxidative capacityBXD miceIsogenic strainsDifferent phenotypesProtein contentMolecular assaysAerobic performanceOxidative capacityMuscle metabolismMetabolismBiogenesisMTCO1AssaysLarge panelBiosynthesisGenes