2024
Rho-Kinase Is Differentially Expressed in the Adipose Tissue of Rodent and Human in Response to Aging, Sex, and Acute Exercise
Muñoz V, Vieira R, Katashima C, Gaspar R, Lino M, dos Santos Trombeta J, Duft R, Macêdo A, da Silva A, Ropelle E, de Moura L, Cintra D, Chacon-Mikahil M, Cavaglieri C, Pauli J. Rho-Kinase Is Differentially Expressed in the Adipose Tissue of Rodent and Human in Response to Aging, Sex, and Acute Exercise. The Journals Of Gerontology Series A 2024, 79: glae001. PMID: 38197701, DOI: 10.1093/gerona/glae001.Peer-Reviewed Original ResearchWhite adipose tissueAcute physical exerciseBrown adipose tissueAdipose tissueFemale rodentsInflammatory markersPhysical exerciseROCK activityInguinal white adipose tissueHuman white adipose tissueHigh-fat dietRho-kinasePossible therapeutic targetAcute exerciseAdipokine productionImpaired thermogenesisEndocrine functionMetabolism improvementTherapeutic targetAdipose depotsHuman preadipocytesROCK2 expressionMetabolic stressPreadipocyte differentiationCell senescence
2020
Acute physical exercise increases PI3K‐p110α protein content in the hypothalamus of obese mice
Gaspar R, Nakandakari S, Muñoz V, Vieira R, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases PI3K‐p110α protein content in the hypothalamus of obese mice. Journal Of Anatomy 2020, 238: 743-750. PMID: 33094520, PMCID: PMC7855078, DOI: 10.1111/joa.13342.Peer-Reviewed Original ResearchConceptsObese miceAcute exerciseFood intakePhysical exerciseCumulative food intakeBlood-brain barrierAcute physical exerciseEnergy homeostasis controlSuppressor of cytokineMain adipokinesHypothalamic nucleiPeripheral organsObese animalsLeptin signalingHypothalamusInsulin actionCentral signalingLeptinProtein levelsActivation of phosphoinositideMiceInsulin pathwayExerciseIntakeHomeostasis control
2019
Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise
Minuzzi L, Chupel M, Rama L, Rosado F, Muñoz V, Gaspar R, Kuga G, Furtado G, Pauli J, Teixeira A. Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise. Cytokine 2019, 115: 1-7. PMID: 30616033, DOI: 10.1016/j.cyto.2018.12.006.Peer-Reviewed Original ResearchConceptsMiddle-aged groupAnti-inflammatory cytokinesMaster athletesAcute exerciseIL-1βIL-4IL-10 levelsAcute exercise effectsMiddle age groupIL-17IL-10IL-1raMaximal incremental testIL-6IL-8Mean VOExercise effectsBlood samplesCycle ergometerExercise practiceAthlete groupCytokinesYounger groupYoung adultsIncremental test
2018
Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice
Gaspar R, Muñoz V, Formigari G, Kuga G, Nakandakari S, Botezelli J, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice. Cytokine 2018, 110: 87-93. PMID: 29705396, DOI: 10.1016/j.cyto.2018.04.013.Peer-Reviewed Original ResearchConceptsAcute physical exerciseObese micePhysical exerciseFood intakeArcuate proopiomelanocortin neuronsSerum adiponectin levelsProtein-3 levelsEffects of leptinCentral nervous systemRole of APPL1Proopiomelanocortin neuronsAdiponectin levelsAcute exerciseNervous systemHypothalamusPathophysiological processesAdiponectinAdaptor protein APPL1MiceProtein kinase BLeucine zipper motif 1Kinase BExerciseIntakeProtein content