Cost Effectiveness of Risk-Reducing Mastectomy versus Surveillance in BRCA Mutation Carriers with a History of Ovarian Cancer
Gamble C, Havrilesky L, Myers E, Chino J, Hollenbeck S, Plichta J, Kelly Marcom P, Shelley Hwang E, Kauff N, Greenup R. Cost Effectiveness of Risk-Reducing Mastectomy versus Surveillance in BRCA Mutation Carriers with a History of Ovarian Cancer. Annals Of Surgical Oncology 2017, 24: 3116-3123. PMID: 28699130, PMCID: PMC5990891, DOI: 10.1245/s10434-017-5995-z.Peer-Reviewed Original ResearchConceptsRisk-reducing mastectomyOvarian cancer diagnosisIncremental cost-effectiveness ratioBRCA mutation carriersMonths of lifeMutation carriersMagnetic resonance imagingCancer diagnosisSurvival benefitOvarian cancerMutation statusMost BRCA1/2 mutation carriersThird-party payer perspectiveGreater survival benefitBreast cancer riskBRCA mutation statusBRCA1/2 mutation carriersBRCA2 mutation carriersBRCA2 mutation statusBRCA1 mutation carriersBreast cancer screeningMonte Carlo probabilistic sensitivity analysisCost-effectiveness ratioYears of lifeProbabilistic sensitivity analysesMiniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins
Nichols B, Llopis A, Palmer G, McCachren S, Senlik O, Miller D, Brooke M, Jokerst N, Geradts J, Greenup R, Ramanujam N. Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins. Journal Of Biomedical Optics 2017, 22: 026007-026007. PMID: 28241273, PMCID: PMC5321165, DOI: 10.1117/1.jbo.22.2.026007.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsFemaleHumansMastectomy, SegmentalMiniaturizationMonte Carlo MethodSpectrum AnalysisConceptsBreast tumor marginsDiffuse optical spectroscopyVisible spectral rangeSpectral imaging deviceDiffuse reflectance spectraOptical spectroscopySpectral rangeImaging arrayMorphological landscapeRaster scanningOptical surrogatesImaging devicesQuantitative functional imagingReflectance spectraImaging platformImaging probeMonte CarloCompressive sensingInverse modelContent ratioWavelengthProbeFunctional imagingSpectroscopySpectra