2017
Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins
Nichols B, Llopis A, Palmer G, McCachren S, Senlik O, Miller D, Brooke M, Jokerst N, Geradts J, Greenup R, Ramanujam N. Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins. Journal Of Biomedical Optics 2017, 22: 026007-026007. PMID: 28241273, PMCID: PMC5321165, DOI: 10.1117/1.jbo.22.2.026007.Peer-Reviewed Original ResearchConceptsBreast tumor marginsDiffuse optical spectroscopyVisible spectral rangeSpectral imaging deviceDiffuse reflectance spectraOptical spectroscopySpectral rangeImaging arrayMorphological landscapeRaster scanningOptical surrogatesImaging devicesQuantitative functional imagingReflectance spectraImaging platformImaging probeMonte CarloCompressive sensingInverse modelContent ratioWavelengthProbeFunctional imagingSpectroscopySpectra
2015
A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins
Nichols B, Schindler C, Brown J, Wilke L, Mulvey C, Krieger M, Gallagher J, Geradts J, Greenup R, Von Windheim J, Ramanujam N. A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. PLOS ONE 2015, 10: e0127525. PMID: 26076123, PMCID: PMC4468201, DOI: 10.1371/journal.pone.0127525.Peer-Reviewed Original ResearchConceptsBreast tumor marginsOptical property mapsDiffuse optical spectroscopyImaging systemWhite LED sourceDiffuse reflectance imagesOptical spectroscopyDistribution function analysisFiber optic probeTurbid mediaEmpirical cumulative distribution function (eCDF) analysisLarge tissue areasLED sourcesScattering coefficientSub-pixel resolutionProbe-tissue interfaceIntra-operative toolMorphological landscapeOptic probeImaging platformTime scalesProperty mapsImproved sensitivityEstimation errorSpectrograph