2022
Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth
Grazioplene RG, DeYoung CG, Hampson M, Anticevic A, Pittenger C. Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth. Translational Psychiatry 2022, 12: 328. PMID: 35948535, PMCID: PMC9365814, DOI: 10.1038/s41398-022-02013-w.Peer-Reviewed Original ResearchConceptsWhite matter abnormalitiesObsessive-compulsive disorderObsessive-compulsive symptomsGeneral psychopathologyCorpus callosumWhite matterFractional anisotropyDistinct white matter abnormalitiesAnterior corpus callosumPosterior corpus callosumWhite matter correlatesAge-dependent mannerWhite matter measuresGeneral psychopathology factorWhite matter microstructureThe thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson P, Stein D, van den Heuvel O, Vriend C. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder. Translational Psychiatry 2022, 12: 70. PMID: 35190533, PMCID: PMC8861046, DOI: 10.1038/s41398-022-01823-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainChildHumansMagnetic Resonance ImagingObsessive-Compulsive DisorderThalamusConceptsObsessive-compulsive disorderMagnetic resonance imagingThalamic volumeOCD patientsThalamic subregionsT1-weighted brain magnetic resonance imagingBrain magnetic resonance imagingClinical-level symptomsLarger thalamic volumesPediatric OCD patientsAdult OCD patientsSeparate multiple linear regression modelsVolumetric group differencesThalamus sizeMedicated patientsAdolescent patientsAnterior thalamusHealthy controlsSubregional volumesGeneral populationMedication statusMultiple comparison correctionPatientsResonance imagingIntracranial volume
2019
Structural correlates of the orbitofrontal cortex and amygdala and personality in female adolescents
Delaparte L, Bartlett E, Grazioplene R, Perlman G, Gardus J, DeLorenzo C, Klein D, Kotov R. Structural correlates of the orbitofrontal cortex and amygdala and personality in female adolescents. Psychophysiology 2019, 56: e13376. PMID: 30942481, PMCID: PMC6650330, DOI: 10.1111/psyp.13376.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexOrbitofrontal cortexT1-weighted structural MRIHigher white matter integrityCritical neurodevelopmental periodMultimodal neuroimaging techniquesWhite matter integrityNeurodevelopmental periodAmygdala volumeCortical thicknessBrain regionsStructural MRIUncinate fasciculusFractional anisotropyNeuroimaging techniquesCortexAdolescent girlsStructural correlatesFemale adolescentsDiffusion tensorAmygdalaAdolescenceAssociationAdult samplesHigh neuroticism
2015
Openness to Experience and Intellect Differentially Predict Creative Achievement in the Arts and Sciences
Kaufman S, Quilty L, Grazioplene R, Hirsh J, Gray J, Peterson J, DeYoung C. Openness to Experience and Intellect Differentially Predict Creative Achievement in the Arts and Sciences. Journal Of Personality 2015, 84: 248-258. PMID: 25487993, PMCID: PMC4459939, DOI: 10.1111/jopy.12156.Peer-Reviewed Original ResearchConceptsCreative achievementCognitive abilitiesDivergent thinkingGeneral cognitive abilityDual-process theoryIndependent predictive validityOpenness/IntellectCognitive engagementDiscriminant validityPredictive validityDiverse sampleCreativityScientific creativityArtSemantic informationIntellectAchievementOpennessThinkingExtraversionPerformance measuresPersonalityValidityAbilityParticipants
2014
Subcortical intelligence: Caudate volume predicts IQ in healthy adults
Grazioplene R, Ryman S, Gray J, Rustichini A, Jung R, DeYoung C. Subcortical intelligence: Caudate volume predicts IQ in healthy adults. Human Brain Mapping 2014, 36: 1407-1416. PMID: 25491047, PMCID: PMC6869035, DOI: 10.1002/hbm.22710.Peer-Reviewed Original ResearchConceptsCaudate volumeDopamine receptor availabilityHealthy adultsAttentional functionsVerbal abilityLarge independent samplesIQTotal brain volumeSubcortical structuresIndependent samplesIntelligenceBilateral caudate volumesCaudate morphologyBrain volumeReceptor availabilityPositive associationCaudate nucleusAdultsSignificant positive correlationLearningCaudatePositive correlationAssociation
2012
A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality
Grazioplene R, DeYoung C, Rogosch F, Cicchetti D. A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality. Journal Of Child Psychology And Psychiatry 2012, 54: 872-880. PMID: 23240931, PMCID: PMC3608843, DOI: 10.1111/jcpp.12031.Peer-Reviewed Original Research
2010
Cortical Thickness and Subcortical Gray Matter Reductions in Neuropsychiatric Systemic Lupus Erythematosus
Jung R, Segall J, Grazioplene R, Qualls C, Sibbitt W, Roldan C. Cortical Thickness and Subcortical Gray Matter Reductions in Neuropsychiatric Systemic Lupus Erythematosus. PLOS ONE 2010, 5: e9302. PMID: 20352085, PMCID: PMC2844408, DOI: 10.1371/journal.pone.0009302.Peer-Reviewed Original ResearchConceptsNeuropsychiatric systemic lupus erythematosusSystemic lupus erythematosusNPSLE groupSLE patientsGray matter volumeCortical thicknessLupus erythematosusNeuropsychiatric symptomsMatter volumeCentral nervous system involvementSystemic lupus erythematosus patientsFreeSurfer image analysis suiteLupus erythematosus patientsNervous system involvementSubcortical gray matter volumesGray matter reductionsGroup differencesSubcortical gray matter structuresSubcortical structure volumesRegional gray matter volumeGray matter structuresSLE groupCortical atrophyCortical thinningControl subjectsWhite Matter Integrity, Creativity, and Psychopathology: Disentangling Constructs with Diffusion Tensor Imaging
Jung R, Grazioplene R, Caprihan A, Chavez R, Haier R. White Matter Integrity, Creativity, and Psychopathology: Disentangling Constructs with Diffusion Tensor Imaging. PLOS ONE 2010, 5: e9818. PMID: 20339554, PMCID: PMC2842439, DOI: 10.1371/journal.pone.0009818.Peer-Reviewed Original ResearchConceptsInferior frontal white matterFrontal white matterWhite matter integrityDiffusion tensor imagingFractional anisotropyWhite matterTensor imagingFronto-striatal circuitsFrontal lobe areasYoung adult subjectsSignificant inverse relationshipCortical thicknessNormal subjectsProjection zonesAssociation fibersAdult subjectsBrain regionsWhite matter architectureInverse correlationTesla scannerMetabolite concentrationsLobe areasComposite measurePsychopathologyInverse relationship