2024
The Hierarchical Taxonomy of Psychopathology and the Search for Neurobiological Substrates of Mental Illness: A Systematic Review and Roadmap for Future Research
DeYoung C, Blain S, Latzman R, Grazioplene R, Haltigan J, Kotov R, Michelini G, Venables N, Docherty A, Goghari V, Kallen A, Martin E, Palumbo I, Patrick C, Perkins E, Shackman A, Snyder M, Tobin K. The Hierarchical Taxonomy of Psychopathology and the Search for Neurobiological Substrates of Mental Illness: A Systematic Review and Roadmap for Future Research. Journal Of Psychopathology And Clinical Science 2024, 133: 697-715. PMID: 39480338, PMCID: PMC11529694, DOI: 10.1037/abn0000903.Peer-Reviewed Original ResearchConceptsHierarchical Taxonomy of PsychopathologyTaxonomy of PsychopathologyClinical neuroscience researchHierarchical taxonomyNeuroscience researchAddictions Neuroclinical AssessmentDimensions of psychopathologyResearch Domain CriteriaDepressive symptom dimensionsHuman neuroimaging studiesTraditional psychiatric diagnosesDistress subfactorTransdiagnostic frameworkNeuroclinical AssessmentSymptom dimensionsCategorical nosologyNeurobiological substratesNeurobiological mechanismsNeuroimaging studiesPsychiatric diagnosisHiTOPInternalizing spectrumAssessment batteryPsychopathologyMental illness
2010
White Matter Integrity, Creativity, and Psychopathology: Disentangling Constructs with Diffusion Tensor Imaging
Jung R, Grazioplene R, Caprihan A, Chavez R, Haier R. White Matter Integrity, Creativity, and Psychopathology: Disentangling Constructs with Diffusion Tensor Imaging. PLOS ONE 2010, 5: e9818. PMID: 20339554, PMCID: PMC2842439, DOI: 10.1371/journal.pone.0009818.Peer-Reviewed Original ResearchConceptsInferior frontal white matterFrontal white matterWhite matter integrityDiffusion tensor imagingFractional anisotropyWhite matterTensor imagingFronto-striatal circuitsFrontal lobe areasYoung adult subjectsSignificant inverse relationshipCortical thicknessNormal subjectsProjection zonesAssociation fibersAdult subjectsBrain regionsWhite matter architectureInverse correlationTesla scannerMetabolite concentrationsLobe areasComposite measurePsychopathologyInverse relationship