Tamoxifen and 5-fluorouracil in breast cancer: cytotoxic synergism in vitro.
Benz C, Cadman E, Gwin J, Wu T, Amara J, Eisenfeld A, Dannies P. Tamoxifen and 5-fluorouracil in breast cancer: cytotoxic synergism in vitro. Cancer Research 1983, 43: 5298-303. PMID: 6616464.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCell LineDrug Evaluation, PreclinicalDrug SynergismDrug Therapy, CombinationEstradiolFemaleFluorouracilHumansMethotrexateReceptors, EstradiolReceptors, EstrogenTamoxifenConceptsHormone-dependent human breast cancer cell linesCytotoxic interactionNuclear estrogen receptor levelsEstrogen receptor levelsHuman breast cancer cell linesBreast cancer cell linesMCF-7Nuclear estrogen receptorsMCF-7 cytotoxicityCytosol progesterone receptorGrowth inhibitionCytosol progesteroneCancer cell linesMCF-7 cellsMicroM tamoxifenProgesterone receptorBreast cancerReceptor levelsEstrogen receptorNM estradiolTamoxifenIsobologram analysisClonogenic assayControl valuesCell lines