Manipulating the Reversible Aggregation of Protein Hormones in Secretory Granules
Dannies P. Manipulating the Reversible Aggregation of Protein Hormones in Secretory Granules. BioDrugs 2003, 17: 315-324. PMID: 14498762, DOI: 10.2165/00063030-200317050-00002.Peer-Reviewed Original ResearchMeSH KeywordsBiopharmaceuticsCell AggregationCell DegranulationChemistry, PharmaceuticalHumansPeptide HormonesSecretory VesiclesTechnology, PharmaceuticalConceptsSecretory granule proteinsSecretory granule formationCell typesSecretory granulesGranule formationGranule proteinsDense-core secretory granulesSecretory cell typesFormation of aggregatesMembrane-permeable chelatorCorrect assemblyProtein aggregationProtein aggregatesProtein interfacesSecretory proteinsMonomeric proteinInsoluble aggregatesNative conformationProtein hormonesExact residuesMacromolecular crowdingProtein preparationsProteinHuman prolactinNeuroendocrine cells