1986
Rat growth hormone gene expression is correlated with an unmethylated CGCG sequence near the transcription initiation site.
Strobl J, Dannies P, Thompson E. Rat growth hormone gene expression is correlated with an unmethylated CGCG sequence near the transcription initiation site. Biochemistry 1986, 25: 3640-8. PMID: 3013292, DOI: 10.1021/bi00360a025.Peer-Reviewed Original ResearchConceptsTranscription initiation siteInitiation siteGene expressionRat growth hormone gene expressionMethylation-sensitive restriction enzymesRat growth hormone geneHybrid cellsGene control regionsGrowth hormone geneThai sitesGrowth hormone gene expressionGH3 cellsCGCG sequenceControl regionDNA methylationBp 5Gene regionGH geneHormone geneHormone gene expressionRestriction enzymesMethylation statusRestriction sitesMouse fibroblastsGH gene expression
1985
Cysteamine Causes Reduction of Prolactin Monomers Followed by Aggregation in the Rat Pituitary Gland*
SCAMMELL J, BURRAGE T, EISENFELD A, DANNIES P. Cysteamine Causes Reduction of Prolactin Monomers Followed by Aggregation in the Rat Pituitary Gland*. Endocrinology 1985, 116: 2347-2354. PMID: 3996317, DOI: 10.1210/endo-116-6-2347.Peer-Reviewed Original Research
1983
20K IS BOUND WITH HIGH AFFINITY BY ONE RAT AND ONE OF TWO RABBIT GROWTH HORMONE RECEPTORS
HUGHES J, TOKUHIRO E, STEVEN J, SIMPSON A, FRIESEN H, Dannies P. 20K IS BOUND WITH HIGH AFFINITY BY ONE RAT AND ONE OF TWO RABBIT GROWTH HORMONE RECEPTORS. Endocrinology 1983, 113: 1904-1906. PMID: 6313333, DOI: 10.1210/endo-113-5-1904.Peer-Reviewed Original Research
1982
Somatic cell hybridization of growth hormone-producing rat pituitary cells and mouse fibroblasts results in extinction of growth hormone expression via a defect in growth hormone RNA production.
Strobl J, Dannies P, Thompson E. Somatic cell hybridization of growth hormone-producing rat pituitary cells and mouse fibroblasts results in extinction of growth hormone expression via a defect in growth hormone RNA production. Journal Of Biological Chemistry 1982, 257: 6588-6594. PMID: 6176584, DOI: 10.1016/s0021-9258(20)65183-3.Peer-Reviewed Original ResearchConceptsMouse GH geneGH geneHybrid cellsHybrid cell DNAHigh molecular weight precursorNon-pituitary cellsSomatic cell hybridizationMolecular weight precursorMultiple restriction enzymesStructural geneTranscript degradationMature mRNARestriction enzyme analysisIncomplete transcriptsFlanking sequencesParental cell lineTranscriptional blockRestriction enzyme digestionRNA productionSouthern hybridizationCell hybridizationMRNA sequencesFibroblasts resultsGrowth hormone expressionMouse fibroblast cells
1980
Action of Cholera Toxin on Hormone Synthesis and Release in GH Cells: Evidence that Adenosine 3′,5′-Monophosphate Does Not Mediate the Decrease in Growth Hormone Synthesis Caused by Thyrotropin-Releasing Hormone*
DANNIES P, TASHJIAN A. Action of Cholera Toxin on Hormone Synthesis and Release in GH Cells: Evidence that Adenosine 3′,5′-Monophosphate Does Not Mediate the Decrease in Growth Hormone Synthesis Caused by Thyrotropin-Releasing Hormone*. Endocrinology 1980, 106: 1532-1536. PMID: 6244936, DOI: 10.1210/endo-106-5-1532.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCholera ToxinCyclic AMPGrowth HormoneKineticsPituitary GlandProlactinRatsThyrotropin-Releasing HormoneConceptsGH synthesisCholera toxinIntracellular cAMPWeeks of treatmentThyrotropin-releasing hormoneRelease of PRLHormone synthesisRat pituitary cellsIntracellular PRLGrowth hormone synthesisPRL releaseSimilar lag periodPituitary cellsGH cellsControl valuesPRL synthesisTRHPRLToxinClonal strainsLag periodReleaseCellsCAMPDecreaseHormonal control of tyrosine aminotransferase, prolactin, and growth hormone induction in somatic cell hybrids
Thompson E, Dannies P, Buckler C, Tashjian A. Hormonal control of tyrosine aminotransferase, prolactin, and growth hormone induction in somatic cell hybrids. The Journal Of Steroid Biochemistry And Molecular Biology 1980, 12: 193-210. PMID: 6106733, DOI: 10.1016/0022-4731(80)90269-1.Peer-Reviewed Original Research
1979
Antipsychotic Drugs Inhibit Prolactin Release from Rat Anterior Pituitary Cells in Culture by a Mechanism Not Involving the Dopamine Receptor*
WEST B, DANNIES P. Antipsychotic Drugs Inhibit Prolactin Release from Rat Anterior Pituitary Cells in Culture by a Mechanism Not Involving the Dopamine Receptor*. Endocrinology 1979, 104: 877-880. PMID: 436760, DOI: 10.1210/endo-104-4-877.Peer-Reviewed Original ResearchConceptsRat anterior pituitary cellsAnterior pituitary cellsGH releasePRL releaseControl valuesAntipsychotic drugsDopamine antagonistsDopamine receptorsPituitary cellsInhibition of PRLMicroM pimozideDopamine agonistsHormone releaseD-butaclamolInhibited secretionPRLBromocriptineAntagonistButaclamolInhibitionReceptorsDrugsReleaseCellsHaloperidol
1977
Anti-Estrogenic Compounds Increase Prolactin and Growth Hormone Synthesis in Clonal Strains of Rat Pituitary Cells1
DANNIES P, YEN P, TASHJIAN A. Anti-Estrogenic Compounds Increase Prolactin and Growth Hormone Synthesis in Clonal Strains of Rat Pituitary Cells1. Endocrinology 1977, 101: 1151-1156. PMID: 908269, DOI: 10.1210/endo-101-4-1151.Peer-Reviewed Original Research
1976
A Possible Role of Cyclic AMP in Mediating the Effects of Thyrotropin-Releasing Hormone on Prolactin Release and on Prolactin and Growth Hormone Synthesis in Pituitary Cells in Culture
DANNIES P, GAUTVIK K, TASHJIAN A. A Possible Role of Cyclic AMP in Mediating the Effects of Thyrotropin-Releasing Hormone on Prolactin Release and on Prolactin and Growth Hormone Synthesis in Pituitary Cells in Culture. Endocrinology 1976, 98: 1147-1159. PMID: 177274, DOI: 10.1210/endo-98-5-1147.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneEffects of TRHProlactin releaseCyclic AMP concentrationGrowth hormone productionProlactin synthesisGH cellsGrowth hormone synthesisCyclic AMPPituitary cellsPhosphodiesterase inhibitorHormone productionHormone synthesisNM thyrotropin-releasing hormoneConcentration of TRHIntracellular cyclic AMP concentrationAMP concentrationCyclic AMP accumulationRat pituitary cellsHalf-maximal increaseDibutyryl cyclic AMPLong-term effectsAMP accumulationGrowth hormoneSerum-free medium
1974
Pyroglutamyl-histidyl-prolineamide (TRH). A neurohormone which affects the release and synthesis of prolactin and thyrotropin.
Dannies P, Tashjian A. Pyroglutamyl-histidyl-prolineamide (TRH). A neurohormone which affects the release and synthesis of prolactin and thyrotropin. Israel Medical Association Journal 1974, 10: 1294-304. PMID: 4215776.Peer-Reviewed Original Research