Ability of repetitive Ca2+ spikes to stimulate prolactin release is frequency dependent
Law G, Pachter J, Dannies P. Ability of repetitive Ca2+ spikes to stimulate prolactin release is frequency dependent. Biochemical And Biophysical Research Communications 1989, 158: 811-816. PMID: 2537637, DOI: 10.1016/0006-291x(89)92794-0.Peer-Reviewed Original ResearchConceptsProlactin releaseAnterior pituitary cellsRelease of prolactinSustained elevated levelsCytosolic free Ca2Amount of prolactinSerial declinePeak Ca2Prolactin secretionPerifusion systemPituitary cellsIndo-1Fluorescent Ca2Repetitive Ca2Transient increaseFree Ca2Elevated levelsProlactinMM KClCa2CellsCoincident increaseMinutesReleaseHigh frequency