2024
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findings
2018
Management of the moderately dilated sinus of Valsalva: To cut or not to cut?
Milewski RK, Habertheuer A, Bavaria JE, Vallabhajosyula P. Management of the moderately dilated sinus of Valsalva: To cut or not to cut? Journal Of Thoracic And Cardiovascular Surgery 2018, 155: 526-527. PMID: 29415375, DOI: 10.1016/j.jtcvs.2017.10.002.Peer-Reviewed Original Research
2017
Concomitant antegrade stent grafting of the descending thoracic aorta during transverse hemiarch reconstruction for acute DeBakey I aortic dissection repair improves aortic remodeling
Sultan I, Wallen TJ, Habertheuer A, Siki M, Arnaoutakis GJ, Bavaria J, Szeto WY, Milewski R, Vallabhajosyula P. Concomitant antegrade stent grafting of the descending thoracic aorta during transverse hemiarch reconstruction for acute DeBakey I aortic dissection repair improves aortic remodeling. Journal Of Cardiac Surgery 2017, 32: 581-592. PMID: 28795434, DOI: 10.1111/jocs.13192.Peer-Reviewed Original ResearchConceptsTrue lumen diameterTEVAR groupTrue lumenThoracic aortaLumen diameterHemiarch reconstructionAortic remodelingStent graftingOpen repairAortic diameterAcute DeBakey I aortic dissectionDeBakey I aortic dissectionFalse lumen thrombosis rateThree-dimensional computed tomography scansAortic dissection repairDeBakey I dissectionsDistal aortic remodelingTotal aortic diameterFalse lumen thrombosisAbdominal aortic diameterEndovascular stent graftingEndovascular aortic repairComputed tomography scanArch tearDeBakey IAortic Regurgitation in Acute Type-A Aortic Dissection: A Clinical Classification for the Perioperative Echocardiographer in the Era of the Functional Aortic Annulus
Patel PA, Bavaria JE, Ghadimi K, Gutsche JT, Vallabhajosyula P, Ko HA, Desai ND, Mackay E, Weiss SJ, Augoustides JGT. Aortic Regurgitation in Acute Type-A Aortic Dissection: A Clinical Classification for the Perioperative Echocardiographer in the Era of the Functional Aortic Annulus. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 586-597. PMID: 28927697, DOI: 10.1053/j.jvca.2017.06.014.Peer-Reviewed Educational MaterialsConceptsFunctional aortic annulusAortic annulusAortic regurgitationSurgical therapyAcute Type A Aortic DissectionType A Aortic DissectionPerioperative echocardiographerAcute aortic syndromeCoronary artery involvementAortic syndromeArtery involvementAortic dissectionTransesophageal echocardiographyRoot dissectionAortic rootPatient presentationClinical classificationSurgical experienceAnatomic considerationsClinical approachRegurgitationTherapyEchocardiographersDissectionLatest literatureFate of remnant sinuses of Valsalva in patients with bicuspid and trileaflet valves undergoing aortic valve, ascending aorta, and aortic arch replacement
Milewski RK, Habertheuer A, Bavaria JE, Siki M, Szeto WY, Krause E, Korutla V, Desai ND, Vallabhajosyula P. Fate of remnant sinuses of Valsalva in patients with bicuspid and trileaflet valves undergoing aortic valve, ascending aorta, and aortic arch replacement. Journal Of Thoracic And Cardiovascular Surgery 2017, 154: 421-432. PMID: 28599977, DOI: 10.1016/j.jtcvs.2017.03.150.Peer-Reviewed Original ResearchConceptsAortic valve replacementBicuspid aortic valveAorta replacementTricuspid aortic valveValve replacementAortic valveValsalva dimensionsPreoperative sinusSinus segmentValvular morphologyValvular pathologyElective aortic valve replacementMultivariable Cox regression modelsAortic arch replacementKaplan-Meier analysisAortic valve morphologyCox regression modelAortic valvulopathyArch replacementSurgical managementAortic aneurysmAortic rootLongitudinal sinusValsalva groupPatients
2015
[Retracted] How to Perfuse: Concepts of Cerebral Protection during Arch Replacement
Habertheuer A, Wiedemann D, Kocher A, Laufer G, Vallabhajosyula P. [Retracted] How to Perfuse: Concepts of Cerebral Protection during Arch Replacement. BioMed Research International 2015, 2015: 981813. PMID: 26713319, PMCID: PMC4680049, DOI: 10.1155/2015/981813.Peer-Reviewed Original ResearchConceptsAntegrade cerebral perfusionCerebral protectionCerebral perfusionPerfusion strategyBilateral antegrade cerebral perfusionAvailable surgical strategiesCardiac surgery communityCerebral perfusion strategyComplex aortic pathologiesSingle-center dataDegree of hypothermiaComplete circulatory arrestArch replacementArch surgeryAortic pathologyArch reconstructionCirculatory arrestCirculatory managementEuropean multicenterHypothermic arrestIschemic insultThoracic aneurysmSurgical interventionSurgical strategySurgical approach
2013
Geometric orientation of the aortic neoroot in patients with raphed bicuspid aortic valve disease undergoing primary cusp repair and a root reimplantation procedure†
Vallabhajosyula P, Szeto WY, Komlo CM, Ryan LP, Wallen TJ, Gorman RC, Desai ND, Bavaria JE. Geometric orientation of the aortic neoroot in patients with raphed bicuspid aortic valve disease undergoing primary cusp repair and a root reimplantation procedure†. European Journal Of Cardio-Thoracic Surgery 2013, 45: 174-180. PMID: 23832833, PMCID: PMC3889626, DOI: 10.1093/ejcts/ezt354.Peer-Reviewed Original ResearchConceptsBicuspid aortic valve diseaseAortic insufficiencyAortic valve diseaseCusp repairTransvalvular gradientRoot reimplantationValve diseasePeak gradientAnnular circumferenceFive-year actuarial survivalHigh transvalvular gradientsEffective surgical treatmentAortic root reimplantationType IActuarial freedomActuarial survivalAortic reoperationBAV repairHospital mortalityPreoperative characteristicsRenal failureRetrospective reviewSurgical treatmentEntire cohortAI patients