2023
Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection
Korutla L, Hoffman J, Rostami S, Hu R, Korutla V, Markmann C, Mullan C, Sotolongo A, Habertheuer A, Romano C, Acker M, Sen S, Agarwal D, Jayaraman A, Li B, Davis M, Naji A, Vallabhajosyula P. Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection. American Journal Of Transplantation 2023, 24: 419-435. PMID: 38295008, DOI: 10.1016/j.ajt.2023.10.021.Peer-Reviewed Original ResearchAcute cellular rejectionAllogeneic transplant recipientsTransplant recipientsCellular rejectionHeart transplantationAlloreactive T cell activationEarly acute cellular rejectionT-cell receptor sequencingSyngeneic transplant recipientsCell receptor sequencingClinical heart transplantationT cell clonesNovel candidate biomarkersT cell activationQuantitative RT-PCRRecipient circulationOrgan transplantationT cellsVesicle profilesNoninvasive biomarkersCandidate biomarkersCell activationRegulatory markersDonor cardiomyocytesTransplantation
2011
Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay
Tena A, Vallabhajosyula P, Hawley RJ, Griesemer A, Yamada K, Sachs DH. Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay. Transplantation 2011, 91: 639-644. PMID: 21285918, PMCID: PMC3255479, DOI: 10.1097/tp.0b013e31820b6b52.Peer-Reviewed Original ResearchConceptsThymic tissueT cellsPeripheral bloodSjTREC levelsT-cell receptor excision circlesPeripheral blood mononuclear cellsPeripheral T cell poolT-cell receptor gene rearrangementsMemory T cellsT cell poolBlood mononuclear cellsNaïve T cellsReceptor gene rearrangementsQuantitative PCRDiscordant pigNative thymusThymic biopsiesGraft survivalKidney transplantPolymerase chain reaction analysisExcision circlesMononuclear cellsSurgical removalChain reaction analysisXenogeneic barriers