Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay
Tena A, Vallabhajosyula P, Hawley RJ, Griesemer A, Yamada K, Sachs DH. Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay. Transplantation 2011, 91: 639-644. PMID: 21285918, PMCID: PMC3255479, DOI: 10.1097/tp.0b013e31820b6b52.Peer-Reviewed Original ResearchConceptsThymic tissueT cellsPeripheral bloodSjTREC levelsT-cell receptor excision circlesPeripheral blood mononuclear cellsPeripheral T cell poolT-cell receptor gene rearrangementsMemory T cellsT cell poolBlood mononuclear cellsNaïve T cellsReceptor gene rearrangementsQuantitative PCRDiscordant pigNative thymusThymic biopsiesGraft survivalKidney transplantPolymerase chain reaction analysisExcision circlesMononuclear cellsSurgical removalChain reaction analysisXenogeneic barriers