Assessing the Effect of Immunosuppression on Engraftment of Pancreatic Islets
Vallabhajosyula P, Hirakata A, Shimizu A, Okumi M, Tchipashvili V, Hong H, Yamada K, Sachs DH. Assessing the Effect of Immunosuppression on Engraftment of Pancreatic Islets. Transplantation 2013, 96: 372-378. PMID: 23883972, PMCID: PMC3786704, DOI: 10.1097/tp.0b013e31829f7515.Peer-Reviewed Original ResearchConceptsTriple-drug immunosuppressionIslet functionAllogeneic islet cell transplantationExperimental animalsLong-term islet functionTriple-drug immunosuppressive regimenIntravenous glucose tolerance testEquivalent glycemic controlEffect of immunosuppressionGlucose tolerance testNormal glucose regulationIslet cell transplantationVivo large animal modelLong-term functionIslet equivalents/Large animal modelImmunosuppressive regimenIslet doseImmunologic factorsRecipient weightEngrafted isletsGlycemic controlMinor histocompatibilityImmunosuppressive drugsCell transplantation