The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide
Byrne CD, Wareham NJ, Mistry PK, Phillips D, Martensz ND, Halsall D, Talmud PJ, Humphries SE, Hales CN. The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide. Atherosclerosis 1996, 127: 35-42. PMID: 9006802, DOI: 10.1016/s0021-9150(96)05932-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedApolipoproteins BBiological TransportChylomicronsDNAFatty Acids, NonesterifiedGene DeletionGenotypeHumansImmunoradiometric AssayLipoproteins, VLDLMaleMiddle AgedMyocardial IschemiaPolymerase Chain ReactionPolymorphism, GeneticPostprandial PeriodPrevalenceProtein Sorting SignalsReference ValuesTriglyceridesUltracentrifugationConceptsIschemic heart diseaseFat tolerance testApo B signal peptideFFA concentrationsTolerance testFree fatty acid responsesLower HDL-cholesterol concentrationsFree fatty acid concentrationsHDL cholesterol concentrationsTriglyceride-rich lipoprotein concentrationsHealthy Caucasian menApo B signal peptide genotypesTriglyceride-rich lipoproteinsPost-prandial stateYears of ageFatty acid responsesOnly significant determinantCaucasian manLipoprotein concentrationsFatty acid concentrationsHeart diseaseCholesterol concentrationsSignificant associationGenotype groupsCommon deletion polymorphism