2008
Attenuation of rodent lung ischemia–reperfusion injury by sphingosine 1-phosphate
Moreno-Vinasco L, Jacobson J, Bonde P, Sammani S, Mirzapoiazova T, Vigneswaran W, Garcia J. Attenuation of rodent lung ischemia–reperfusion injury by sphingosine 1-phosphate. Journal Of Organ Dysfunction 2008, 4: 106-114. DOI: 10.1080/17471060701505289.Peer-Reviewed Original ResearchLung ischemia-reperfusion injuryIschemia-reperfusion injuryIR injuryBronchoalveolar lavage inflammatory cellsPronounced anti-inflammatory effectLung myeloperoxidase activityLung preservation strategiesLung preservation techniquesPulmonary artery ligationAnti-inflammatory effectsLung vascular permeabilityBAL neutrophilsAlveolar damageDonor lungsMyeloperoxidase activityTransplant failureArtery ligationBAL fluidLeukocyte infiltrationSubsequent reperfusionIL-1βIL-6Inflammatory cellsIL-2Rat model
2006
71 SIMVASTATIN ATTENUATES ACUTE LUNG INJURY INDUCED BY ISCHEMIA-REPERFUSION IN RODENTS.
Moreno L, Jacobson J, Bonde P, Garcia J. 71 SIMVASTATIN ATTENUATES ACUTE LUNG INJURY INDUCED BY ISCHEMIA-REPERFUSION IN RODENTS. Journal Of Investigative Medicine 2006, 54: s355. DOI: 10.2310/6650.2005.x0015.70.Peer-Reviewed Original ResearchIR injuryLung injuryAnimal modelsACUTE LUNG INJURY INDUCEDLung tissue myeloperoxidase activityBronchoalveolar lavage cell countsIschemia-reperfusion lung injuryIndices of inflammationIR lung injuryLavage cell countsLung preservation techniquesTissue myeloperoxidase activityHours of reperfusionLeft pulmonary arteryPotential therapeutic roleAnesthetized Sprague-DawleySignificant clinical impactProfound clinical implicationsLung transplantationTissue MPOAlveolar damageMyeloperoxidase activityTransplant failurePulmonary arterySimvastatin treatment