Inhibition of the EGFR and hedgehog signaling pathways demonstrate potent growth inhibition in an animal model of esophageal carcinogenesis
Sui G, Bonde P, Dhara S, Marti G, Freguson M, Wang J, Jaffee E, Duncan M, Montgomery E, Maitra A, Harmon J. Inhibition of the EGFR and hedgehog signaling pathways demonstrate potent growth inhibition in an animal model of esophageal carcinogenesis. Journal Of Surgical Research 2004, 121: 278-279. DOI: 10.1016/j.jss.2004.07.040.Peer-Reviewed Original ResearchEpidermal growth factor receptorSignificant growth inhibitionEsophageal carcinogenesisCell linesVivo growthGrowth inhibitionSquamous cell carcinomaSprague-Dawley ratsReliable preclinical modelsHh pathway antagonistsImportant oncogenic pathwaysBilious refluxMock-treated cellsGrowth factor receptorAdenosquamous cancerCell carcinomaEsophageal cancerSD ratsPreclinical modelsSubcutaneous xenograftsAthymic miceSmall molecule inhibitorsAnimal modelsPotent growth inhibitionExperimental therapeutics