DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury
Bonde P, Gao D, Chen L, Moreno-Vinasco L, Jacobson J, Garcia J, Wei C. DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury. Journal Of Cardiothoracic-Renal Research 2006, 1: 147-152. DOI: 10.1016/j.jccr.2006.05.007.Peer-Reviewed Original ResearchLung ischemiaLung transplantationReperfusion groupReperfusion injuryWestern blotDNA mismatch repair pathwayAdult Sprague-Dawley ratsMismatch repair pathwaySprague-Dawley ratsModel of ischemiaAttractive therapeutic interventionCaspase-3 immunohistochemistryDNA damageCaspase-3 levelsDawley ratsLung tissueOxidative DNA damageReperfusionDNA repair enzymeIschemiaTherapeutic interventionsImmunohistochemistryRepair pathwaysProtein levelsTransplantationOxidative DNA damage and DNA mismatch repair pathway play an important role in failing human myocardium
Lin R, Gao D, Gu Y, Bonde P, Fitton T, Hare J, Conte J, Williams G, Wei C. Oxidative DNA damage and DNA mismatch repair pathway play an important role in failing human myocardium. Journal Of Cardiothoracic-Renal Research 2006, 1: 41-49. DOI: 10.1016/j.jccr.2005.11.004.Peer-Reviewed Original ResearchApoptosis-related genesDNA damageRepair enzymesDNA mismatch repair pathwayImmunohistochemical stainingHuman myocardiumMismatch repair pathwayCaspase-3Donor subjectsDNA repair enzymeProtein levelsHearts of patientsDNA reconstructionRepair pathwaysOxidative DNA damageLevel of apoptosisCHF myocardiumCardiac transplantationCHF patientsBackgroundHeart failureMyocardial failureResultsThe levelsEpidemic proportionsImportant roleMyocardium