2017
Cdk1‐interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stress
Zhang Z, Ren P, Vashisht AA, Wohlschlegel JA, Quintana DG, Zeng F. Cdk1‐interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stress. Genes To Cells 2017, 22: 850-860. PMID: 28771906, PMCID: PMC5643225, DOI: 10.1111/gtc.12518.Peer-Reviewed Original ResearchConceptsS-phase checkpointGenotoxic stressPhase checkpointG1 cyclin Cln2Rad53-dependent mannerCDK1 inhibitorS-phase checkpoint responseYeast Saccharomyces cerevisiaeMec1-dependent mannerATM/ATRDe novo protein synthesisCell cycle progressionDependent kinase inhibitorNovo protein synthesisTQ motifsChromosome replicationEukaryotic cellsReplication stressCheckpoint responseChromosomal replicationDownstream kinasesSaccharomyces cerevisiaeGenomic instabilityCycle progressionG1 cyclins
2015
G1 cyclin driven DNA replication
Palou R, Malik A, Palou G, Zeng F, Ren P, Quintana DG. G1 cyclin driven DNA replication. Cell Cycle 2015, 14: 3842-3850. PMID: 26176277, PMCID: PMC4825731, DOI: 10.1080/15384101.2015.1070995.Peer-Reviewed Original ResearchConceptsCyclin-dependent kinasesDNA replicationPhase cyclinsCycle eventsCell cycleCDK catalytic subunitPhase-specific transcriptionIntrinsic substrate specificityMitotic cell cycleCell cycle eventsS phase cyclinsG1 phase cyclinsChromosome segregationSpecific transcriptionCDK activationCatalytic subunitCDK activitySubstrate specificityG1 cyclinsCyclinSuch regulationSubunitsReplicationHigh enough levelsQuantitative control