2016
Identification of YPL014W (Cip1) as a novel negative regulator of cyclin‐dependent kinase in Saccharomyces cerevisiae
Ren P, Malik A, Zeng F. Identification of YPL014W (Cip1) as a novel negative regulator of cyclin‐dependent kinase in Saccharomyces cerevisiae. Genes To Cells 2016, 21: 543-552. PMID: 27005485, DOI: 10.1111/gtc.12361.Peer-Reviewed Original ResearchConceptsCyclin-dependent kinasesNovel negative regulatorNegative regulatorCell division cycle progressionCycle progressionCell cycleModel eukaryotic organism SaccharomycesSingle cyclin-dependent kinaseCdk1-dependent mannerWild-type cellsBlocks cell cycle progressionCell cycle progressionClb5-Cdk1Organism SaccharomycesEukaryotic cellsGenomic instabilityUnscheduled proliferationKinaseCIP1SaccharomycesCDK1RegulatorSic1CellsCerevisiae
2015
G1 cyclin driven DNA replication
Palou R, Malik A, Palou G, Zeng F, Ren P, Quintana DG. G1 cyclin driven DNA replication. Cell Cycle 2015, 14: 3842-3850. PMID: 26176277, PMCID: PMC4825731, DOI: 10.1080/15384101.2015.1070995.Peer-Reviewed Original ResearchConceptsCyclin-dependent kinasesDNA replicationPhase cyclinsCycle eventsCell cycleCDK catalytic subunitPhase-specific transcriptionIntrinsic substrate specificityMitotic cell cycleCell cycle eventsS phase cyclinsG1 phase cyclinsChromosome segregationSpecific transcriptionCDK activationCatalytic subunitCDK activitySubstrate specificityG1 cyclinsCyclinSuch regulationSubunitsReplicationHigh enough levelsQuantitative control