2023
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalitiesIntegrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application
Heerdt P, Martin-Flores M, Oakland H, Joseph P, Singh I. Integrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1929-1937. PMID: 37422337, PMCID: PMC10529383, DOI: 10.1053/j.jvca.2023.06.011.Peer-Reviewed Original ResearchConceptsRight heart catheterizationHeart catheterizationDiastolic functionRV volumesBeat measuresDiagnostic right heart catheterizationReference standardRight ventricular contractilityEnd-diastolic pressurePressure waveform analysisEnd-systolic elastancePotential clinical utilityClinical applicationRV volume measurementsVolume measurementsRV contractilityRV systolicVentricular contractilityRV pressureBland-Altman analysisClinical utilityAnesthetized swineNitric oxideExperimental modelContractilityNoninvasive determinants of pulmonary hypertension in interstitial lung disease
Joseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.Peer-Reviewed Original ResearchInterstitial lung diseaseFVC/DLCO ratioPH-ILDRight heart catheterizationPulmonary hypertensionHeart catheterizationILD patientsLung diseaseDiagnostic right heart catheterizationRight ventricular systolic pressurePulmonary vascular capacitanceVentricular systolic pressureCharacteristic curve analysisMaximum oxygen uptakeExertional capacityNoninvasive determinantsSystolic pressureVascular capacitancePhysiologic evaluationPatientsNoninvasive variablesMultivariate analysisMmHgDiagnostic standardPotential initiation
2022
Cardiopulmonary Exercise Testing in Pulmonary Vascular Disease
Joseph P, Systrom D. Cardiopulmonary Exercise Testing in Pulmonary Vascular Disease. 2022, 582-596. DOI: 10.1016/b978-0-12-801238-3.11478-3.ChaptersInvasive cardiopulmonary exercise testingCardiopulmonary exercise testingPulmonary vascular diseaseArtery catheterExercise testingCardiac outputPulmonary circulationVascular diseaseNoninvasive cardiopulmonary exercise testingNormal diagnostic workupPulmonary parenchymal diseaseRight heart catheterizationPulmonary arterial hypertensionPulmonary artery catheterArterial blood gasesRadial artery catheterModern medical therapyUseful screening testFick cardiac outputMeasurements of rightArterial hypertensionHeart catheterizationPulmonary hypertensionVenous hypertensionExercise impairment
2020
Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction
Oakland HT, Joseph P, Elassal A, Cullinan M, Heerdt PM, Singh I. Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction. Pulmonary Circulation 2020, 10: 1-10. PMID: 33282205, PMCID: PMC7691918, DOI: 10.1177/2045894020972273.Peer-Reviewed Original ResearchIsolated post-capillary pulmonary hypertensionPost-capillary pulmonary hypertensionCardiopulmonary exercise testRight heart catheterizationPulmonary vascular capacitanceVE/VCOPulmonary hypertensionEnd-tidal carbon dioxideEjection fractionHeart failureExercise testHeart catheterizationVascular capacitanceCombined preElevated left-sided filling pressuresLeft-sided filling pressuresGender-matched control subjectsOxygen uptake efficiency slopeCarbon dioxide slopeCardiopulmonary exercise testingPulmonary artery complianceEnd-tidal COAdjunct diagnostic toolMaximum oxygen uptakeGreater ventilatoryFick principle and exercise pulmonary hemodynamic determinants of the six‐minute walk distance in pulmonary hypertension
Joseph P, Oliveira RKF, Eslam RB, Agarwal M, Waxman AB, Systrom DM. Fick principle and exercise pulmonary hemodynamic determinants of the six‐minute walk distance in pulmonary hypertension. Pulmonary Circulation 2020, 10: 1-9. PMID: 32994925, PMCID: PMC7502687, DOI: 10.1177/2045894020957576.Peer-Reviewed Original ResearchSix-minute walk distanceSix-minute walk testWalk distancePulmonary hypertensionOxygen deliveryCardiac reserveWalk testHemodynamic determinantsFick principleMixed venous blood samplesDepressed cardiac indexRight heart afterloadPulmonary vascular resistanceRight heart catheterizationRight ventricular afterloadStroke volume indexTotal pulmonary resistancePulmonary artery catheterPulmonary vascular pressuresSystemic oxygen deliveryVenous blood samplesImpaired oxygen deliveryFick cardiac outputCardiac indexHeart catheterization