2023
Response to letter to the editor “noninvasive determinants of pulmonary hypertension in interstitial lung disease”
Joseph P, Savarimuthu S, Oakland H, Cullinan M, Heerdt P, Singh I. Response to letter to the editor “noninvasive determinants of pulmonary hypertension in interstitial lung disease”. Pulmonary Circulation 2023, 13: e12238. PMID: 37180828, PMCID: PMC10166920, DOI: 10.1002/pul2.12238.Peer-Reviewed Original ResearchInterstitial lung diseaseNoninvasive determinantsPulmonary hypertensionLung diseaseHypertensionDiseaseNoninvasive determinants of pulmonary hypertension in interstitial lung disease
Joseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.Peer-Reviewed Original ResearchInterstitial lung diseaseFVC/DLCO ratioPH-ILDRight heart catheterizationPulmonary hypertensionHeart catheterizationILD patientsLung diseaseDiagnostic right heart catheterizationRight ventricular systolic pressurePulmonary vascular capacitanceVentricular systolic pressureCharacteristic curve analysisMaximum oxygen uptakeExertional capacityNoninvasive determinantsSystolic pressureVascular capacitancePhysiologic evaluationPatientsNoninvasive variablesMultivariate analysisMmHgDiagnostic standardPotential initiation
2022
Cardiopulmonary Exercise Testing in Pulmonary Vascular Disease
Joseph P, Systrom D. Cardiopulmonary Exercise Testing in Pulmonary Vascular Disease. 2022, 582-596. DOI: 10.1016/b978-0-12-801238-3.11478-3.ChaptersInvasive cardiopulmonary exercise testingCardiopulmonary exercise testingPulmonary vascular diseaseArtery catheterExercise testingCardiac outputPulmonary circulationVascular diseaseNoninvasive cardiopulmonary exercise testingNormal diagnostic workupPulmonary parenchymal diseaseRight heart catheterizationPulmonary arterial hypertensionPulmonary artery catheterArterial blood gasesRadial artery catheterModern medical therapyUseful screening testFick cardiac outputMeasurements of rightArterial hypertensionHeart catheterizationPulmonary hypertensionVenous hypertensionExercise impairment
2021
Sex Differences and the Role of Sex Hormones in Pulmonary Hypertension
Oakland HT, Joseph P. Sex Differences and the Role of Sex Hormones in Pulmonary Hypertension. Clinics In Chest Medicine 2021, 42: 457-465. PMID: 34353451, DOI: 10.1016/j.ccm.2021.04.006.ChaptersConceptsPulmonary hypertensionProgressive pulmonary vascular remodelingRight heart failurePulmonary arterial hypertensionPulmonary vascular remodelingSex differencesArterial hypertensionHeart failureFemale sexSex hormonesVascular remodelingHypertensionFuture treatmentBeneficial effectsEventual developmentMultiple mechanismsVasoconstrictionEarlier descriptionsInflammationPathophysiologyEstrogenPrevalenceDiseaseHormoneArterial load and right ventricular-vascular coupling in pulmonary hypertension
Oakland H, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. Arterial load and right ventricular-vascular coupling in pulmonary hypertension. Journal Of Applied Physiology 2021, 131: 424-433. PMID: 34043473, PMCID: PMC8325619, DOI: 10.1152/japplphysiol.00204.2021.Peer-Reviewed Original ResearchConceptsPulmonary artery hypertensionRV-PA uncouplingPulmonary vascular resistancePressure waveform analysisRight ventriclePulmonary vascular impedancePulmonary hypertensionVascular impedanceRight heart catheterization dataRight ventricular-vascular couplingRV-pulmonary arterial couplingCpc-PH groupEjection fraction patientsHeart catheterization dataRV pressure curveRV-PA couplingLeft heart diseaseVentricular-vascular couplingSex-matched controlsAfterload parametersCpc-PHIpc-PHPH-HFpEFRV afterloadArtery hypertension
2020
Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction
Oakland HT, Joseph P, Elassal A, Cullinan M, Heerdt PM, Singh I. Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction. Pulmonary Circulation 2020, 10: 1-10. PMID: 33282205, PMCID: PMC7691918, DOI: 10.1177/2045894020972273.Peer-Reviewed Original ResearchIsolated post-capillary pulmonary hypertensionPost-capillary pulmonary hypertensionCardiopulmonary exercise testRight heart catheterizationPulmonary vascular capacitanceVE/VCOPulmonary hypertensionEnd-tidal carbon dioxideEjection fractionHeart failureExercise testHeart catheterizationVascular capacitanceCombined preElevated left-sided filling pressuresLeft-sided filling pressuresGender-matched control subjectsOxygen uptake efficiency slopeCarbon dioxide slopeCardiopulmonary exercise testingPulmonary artery complianceEnd-tidal COAdjunct diagnostic toolMaximum oxygen uptakeGreater ventilatoryFick principle and exercise pulmonary hemodynamic determinants of the six‐minute walk distance in pulmonary hypertension
Joseph P, Oliveira RKF, Eslam RB, Agarwal M, Waxman AB, Systrom DM. Fick principle and exercise pulmonary hemodynamic determinants of the six‐minute walk distance in pulmonary hypertension. Pulmonary Circulation 2020, 10: 1-9. PMID: 32994925, PMCID: PMC7502687, DOI: 10.1177/2045894020957576.Peer-Reviewed Original ResearchSix-minute walk distanceSix-minute walk testWalk distancePulmonary hypertensionOxygen deliveryCardiac reserveWalk testHemodynamic determinantsFick principleMixed venous blood samplesDepressed cardiac indexRight heart afterloadPulmonary vascular resistanceRight heart catheterizationRight ventricular afterloadStroke volume indexTotal pulmonary resistancePulmonary artery catheterPulmonary vascular pressuresSystemic oxygen deliveryVenous blood samplesImpaired oxygen deliveryFick cardiac outputCardiac indexHeart catheterization