2007
From prediction error to psychosis: ketamine as a pharmacological model of delusions
Corlett PR, Honey GD, Fletcher PC. From prediction error to psychosis: ketamine as a pharmacological model of delusions. Journal Of Psychopharmacology 2007, 21: 238-252. PMID: 17591652, DOI: 10.1177/0269881107077716.Peer-Reviewed Original ResearchConceptsDelusion formationAssociative learning processesPrediction error signalsDevelopment of delusionsFormation of delusionsPre-psychotic periodAttentional disruptionAttentional disturbancesNeuropsychiatric modelsNeurobiological systemsPrediction errorExperience resultsLearning processIrrelevant detailsDelusionsError signalDrug ketaminePsychosisNumerous associationsPsychotic statesPerceptExpectationsPharmacological modelStimuliSymptom evolution
2006
Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis
Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC. Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis. JAMA Psychiatry 2006, 63: 611-621. PMID: 16754834, DOI: 10.1001/archpsyc.63.6.611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAssociation LearningBrief Psychiatric Rating ScaleCognition DisordersDelusionsDisease SusceptibilityDose-Response Relationship, DrugFemaleFrontal LobeHumansKetamineMagnetic Resonance ImagingMaleModels, TheoreticalPerceptual DisordersPlacebosProbabilityPsychiatric Status Rating ScalesPsychoses, Substance-InducedPsychotic DisordersConceptsDelusion formationPerceptual AberrationBrain activityError-dependent learningPharmacological functional magnetic resonanceAssociative learning taskFunctional magnetic resonance imagingAssociative learning processesDelusion-like beliefsFrontal cortical functionFunctional magnetic resonanceFull Scale IQUnderstanding of psychosisRight frontal cortexRight-handed volunteersNeurobiological accountsCognitive processesClinical Neuroscience InstituteFrontal activationAssociative learningFrontal responseBrain activationStructured Clinical InterviewLearning taskPsychotogenic effects