2021
Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury
Nakazaki M, Morita T, Lankford KL, Askenase PW, Kocsis JD. Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury. Journal Of Extracellular Vesicles 2021, 10: e12137. PMID: 34478241, PMCID: PMC8408371, DOI: 10.1002/jev2.12137.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem/stromal cellsSpinal cord injuryBlood-spinal cord barrierSmall extracellular vesiclesFunctional recoveryM2 macrophagesCord injuryInjury siteTherapeutic effectStromal cellsSevere spinal cord injurySingle MSC injectionImproved functional recoveryBone marrow-derived mesenchymal stem/stromal cellsM2 macrophage markersSimilar therapeutic effectsRelease of sEVsMesenchymal stem/stromal cellsExtracellular vesiclesTight junction proteinsStem/stromal cellsMesenchymal stromal cellsTGF-β receptorMSC infusionSCI rats
2008
Identification of Initiator B Cells, a Novel Subset of Activation-Induced Deaminase-Dependent B-1-Like Cells That Mediate Initiation of Contact Sensitivity
Kerfoot SM, Szczepanik M, Tung JW, Askenase PW. Identification of Initiator B Cells, a Novel Subset of Activation-Induced Deaminase-Dependent B-1-Like Cells That Mediate Initiation of Contact Sensitivity. The Journal Of Immunology 2008, 181: 1717-1727. PMID: 18641308, DOI: 10.4049/jimmunol.181.3.1717.Peer-Reviewed Original ResearchConceptsContact sensitivityB cellsCS initiationInflammatory responseT cell-mediated inflammationProinflammatory T cellsCell-mediated inflammationAdoptive transfer experimentsDelayed-type hypersensitivityAg-specific IgMReceptor gene mutationsSensitized miceVascular activationDeficient recipientsT cellsNovel subsetSomatic hypermutationNovel subpopulationGene mutationsIgMMiceActivation-Induced DeaminaseWT cellsCellsChain gene