2013
Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity
Bryniarski K, Ptak W, Jayakumar A, Püllmann K, Caplan MJ, Chairoungdua A, Lu J, Adams BD, Sikora E, Nazimek K, Marquez S, Kleinstein SH, Sangwung P, Iwakiri Y, Delgato E, Redegeld F, Blokhuis BR, Wojcikowski J, Daniel AW, Kormelink T, Askenase PW. Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity. Journal Of Allergy And Clinical Immunology 2013, 132: 170-181.e9. PMID: 23727037, PMCID: PMC4176620, DOI: 10.1016/j.jaci.2013.04.048.Peer-Reviewed Original ResearchConceptsCutaneous contact sensitivityEffector T cellsT cell toleranceT cellsExosome-like nanovesiclesContact sensitivityCS-effector T cellsMiRNA-150Regulatory T cellsAntigen-specific mannerSuppressor T cellsRole of antibodiesAdoptive cell transfer modelCell transfer modelT cell regulationLight chainSuppressor cellsLymph nodesReactive haptenImmune suppressionMicroRNA-150Systemic injectionAntibody light chainIntravenous injectionSpleen cells
2006
Interleukin 5 Plays an Essential Role in Elicitation of Contact Sensitivity through Dual Effects on Eosinophils and B-1 Cells
Itakura A, Kikuchi Y, Kouro T, Ikutani M, Takaki S, Askenase PW, Takatsu K. Interleukin 5 Plays an Essential Role in Elicitation of Contact Sensitivity through Dual Effects on Eosinophils and B-1 Cells. International Archives Of Allergy And Immunology 2006, 140: 8-16. PMID: 16772721, DOI: 10.1159/000092705.Peer-Reviewed Original ResearchConceptsElicitation of CSIgM-producing cellsContact sensitivityEosinophil peroxidase activityEosinophil infiltrationIL-5Antigen-specific immunoglobulin M antibodyCS-effector T cellsEnzyme-linked immunospot assayLocal tissueEffector T cellsRole of interleukinImmunoglobulin M antibodiesIL-5 receptorImmunized ILImmunospot assayContact sensitizationM antibodiesMononuclear cellsDeficient micePolymorphonuclear cellsT cellsImmune responseCell activationInterleukin-5
1992
Role of Gamma/Delta T Cells as Positive Regulators of Alpha/Beta TCR+ Effector T Cells in Allergic Contact Sensitivity
Askenase PW, Ptak W. Role of Gamma/Delta T Cells as Positive Regulators of Alpha/Beta TCR+ Effector T Cells in Allergic Contact Sensitivity. International Archives Of Allergy And Immunology 1992, 99: 246-251. PMID: 34167199, DOI: 10.1159/000236258.Peer-Reviewed Original ResearchCutaneous contact sensitivityEffector T cellsCS-effector T cellsT cell receptorΓδ T cellsT cellsCS responsesContact sensitivityGamma/delta T cellsCell transferCS effector cellsDelta T cellsMinor histocompatibility antigensAdoptive cell transferΑβ T cellsAllergic contact sensitivityTCR mAbEffector cellsΓδ TΑβ TAlpha/betaRabbit complementHistocompatibility antigensVitro treatmentCell receptor