Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion
White AP, Vaccaro AR, Hall JA, Whang PG, Friel BC, McKee MD. Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion. International Orthopaedics 2007, 31: 735-741. PMID: 17962946, PMCID: PMC2266670, DOI: 10.1007/s00264-007-0422-x.Peer-Reviewed Original ResearchConceptsBone morphogenetic protein-7Tibial fracturesSpinal fusionOP-1Bony fusion massDistal tibial fracturesLong bone nonunionOpen tibial fracturesRoute of administrationFuture clinical investigationsUse of BMPLong bone applicationsRecombinant human OP-1Collagen matrix resultsSupportive evidenceScaphoid nonunionClinical outcomesTibial nonunionClinical trialsClinical studiesBone nonunionClinical investigationNew therapeutic applicationsAnimal modelsMorphogenetic protein-7