2007
Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion
White AP, Vaccaro AR, Hall JA, Whang PG, Friel BC, McKee MD. Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion. International Orthopaedics 2007, 31: 735-741. PMID: 17962946, PMCID: PMC2266670, DOI: 10.1007/s00264-007-0422-x.Peer-Reviewed Original ResearchConceptsBone morphogenetic protein-7Tibial fracturesSpinal fusionOP-1Bony fusion massDistal tibial fracturesLong bone nonunionOpen tibial fracturesRoute of administrationFuture clinical investigationsUse of BMPLong bone applicationsRecombinant human OP-1Collagen matrix resultsSupportive evidenceScaphoid nonunionClinical outcomesTibial nonunionClinical trialsClinical studiesBone nonunionClinical investigationNew therapeutic applicationsAnimal modelsMorphogenetic protein-7
2006
Animal models of spine fusion and low back pain
Poelstra K, Austin L, Zaslavsky J, Whang P, Patel A. Animal models of spine fusion and low back pain. Current Orthopaedic Practice 2006, 17: 214-221. DOI: 10.1097/01.bco.0000223529.57395.b8.Peer-Reviewed Original ResearchAnimal modelsCircumferential spinal fusionLow back painNew treatment strategiesReviews animal modelsBasic science advancesIntervertebral disc degenerationProgressive diseaseBack painTreatment strategiesSpinal fusionSpine fusionImproved careSurgical solutionPatient careDisc degenerationPainCarePivotal roleOsteoinductive agentsWide spectrumPatientsDegenerationDiseaseSurgeons