2012
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modeling
2002
Interneuronal and Peptidergic Control of Motor Pattern Switching in Aplysia
Morgan PT, Jing J, Vilim FS, Weiss KR. Interneuronal and Peptidergic Control of Motor Pattern Switching in Aplysia. Journal Of Neurophysiology 2002, 87: 49-61. PMID: 11784729, DOI: 10.1152/jn.00438.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCluster AnalysisElectric StimulationFeeding BehaviorGanglia, InvertebrateImmunohistochemistryIn Vitro TechniquesInterneuronsMembrane PotentialsMotor NeuronsNeuropeptidesPeptidesPhysical StimulationSignal Processing, Computer-AssistedStimulation, ChemicalSynaptic TransmissionConceptsCBI-3Higher-order neuronsCBI-2Order neuronsMotor programsCentral pattern generatorIngestive programsSuch neuronsIngestive onesNeuronsConcomitant activationPeptidergic controlSingle central pattern generatorUse of modulatorsStimulus conditionsActivationElectrical couplingAplysiaAppropriate stimulus conditionsAdditional supportPattern generatorNeuropeptides