2014
Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals
Fox HC, Morgan PT, Sinha R. Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals. Neuropsychopharmacology 2014, 39: 1527-1537. PMID: 24395021, PMCID: PMC3988558, DOI: 10.1038/npp.2014.1.Peer-Reviewed Original ResearchConceptsCocaine use disorderImagery conditionNegative emotionsDrug cravingUse disordersCocaine-dependent individualsCocaine-dependent malesCocaine-dependent menSex differencesGuanfacine's effectsDrug cuesImagery exposureNegative moodSystolic blood pressureStress arousalNicotine cravingAlcohol cravingCounterbalanced orderCravingCocaine cravingAnxietyCocaine addictionEmotionsRecovery time pointsGuanfacine
2013
The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type
Fox HC, Sofuoglu M, Morgan PT, Tuit KL, Sinha R. The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type. Psychoneuroendocrinology 2013, 38: 1532-1544. PMID: 23374328, PMCID: PMC3772967, DOI: 10.1016/j.psyneuen.2012.12.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultAffectAlcohol DrinkingAnxietyArousalBlood PressureCocaine-Related DisordersComorbidityCuesDepressionDouble-Blind MethodEmotionsEstradiolFemaleHeart RateHumansHydrocortisoneHypothalamo-Hypophyseal SystemImagery, PsychotherapyMaleMiddle AgedPituitary-Adrenal SystemProgesteroneRelaxation TherapySex CharacteristicsSmokingStress, PsychologicalStroop TestConceptsDrug cravingCocaine-dependent menCognitive performanceStress arousalTreatment-seeking cocaine dependent individualsCue-induced cravingCocaine-dependent individualsCue typesStroop performanceSubjective cravingCognitive measuresImagery conditionNegative emotionsCue exposureInhibitory controlRelaxed moodDependent individualsDependent menArousal stateCravingArousalCounterbalanced orderStress exposureRewarding effectsCocaine dependence
2007
Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females
Fox HC, Hong KA, Paliwal P, Morgan PT, Sinha R. Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females. Psychopharmacology 2007, 195: 527-536. PMID: 17891383, PMCID: PMC2746368, DOI: 10.1007/s00213-007-0936-3.Peer-Reviewed Original ResearchConceptsMenstrual cycleSex hormonesHealthy femalesEstradiol/progesterone ratioSteroid hormonesFirst monthChronic cocaine abuseSex steroid hormonesLevels of cortisolMood rating scalesStress steroid hormonesDrug-seeking behaviorProgesterone ratioHealthy controlsInpatient treatmentObjectivesThe current studyEvidence of alterationsBrain stressCocaine cravingCocaine abuseSalivary samplesCocaine abstinenceCocaine dependenceCocaine reinforcementCocaine patients