2010
Normalizing Effects of Modafinil on Sleep in Chronic Cocaine Users
Morgan PT, Pace-Schott E, Pittman B, Stickgold R, Malison RT. Normalizing Effects of Modafinil on Sleep in Chronic Cocaine Users. American Journal Of Psychiatry 2010, 167: 331-340. PMID: 20080983, PMCID: PMC5857958, DOI: 10.1176/appi.ajp.2009.09050613.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzhydryl CompoundsCentral Nervous System StimulantsCocaineCocaine-Related DisordersDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleHumansMaleMiddle AgedModafinilPolysomnographySleep Wake DisordersSubstance Abuse Treatment CentersSubstance Withdrawal SyndromeWakefulnessConceptsMultiple sleep latency testSlow-wave sleep timeSleep latency testEffects of modafinilTotal sleep timeSleep latencyCocaine-dependent participantsSleep timeChronic cocaine usersDaytime sleepinessLatency testCocaine usersShorter REM sleep latencyDaytime sleep latencyLonger total sleep timeREM sleep latencySubjective daytime sleepinessSleep architecture variablesPolysomnographic sleep recordingsSleep architectureNocturnal sleepHealthy comparison participantsAbstinent cocaine usersDay 1Day 2
2007
Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females
Fox HC, Hong KA, Paliwal P, Morgan PT, Sinha R. Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females. Psychopharmacology 2007, 195: 527-536. PMID: 17891383, PMCID: PMC2746368, DOI: 10.1007/s00213-007-0936-3.Peer-Reviewed Original ResearchConceptsMenstrual cycleSex hormonesHealthy femalesEstradiol/progesterone ratioSteroid hormonesFirst monthChronic cocaine abuseSex steroid hormonesLevels of cortisolMood rating scalesStress steroid hormonesDrug-seeking behaviorProgesterone ratioHealthy controlsInpatient treatmentObjectivesThe current studyEvidence of alterationsBrain stressCocaine cravingCocaine abuseSalivary samplesCocaine abstinenceCocaine dependenceCocaine reinforcementCocaine patients