2023
Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency
Little J, Oakley M, Thorner A, Johnston D, Majam V, Liakos A, Novack L, Zheng H, Meredith S, Chou C, Newton B, Soiffer R, Krause P, Baden L, Kumar S. Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency. Open Forum Infectious Diseases 2023, 11: ofad568. PMID: 38213635, PMCID: PMC10783156, DOI: 10.1093/ofid/ofad568.Peer-Reviewed Original ResearchB-cell deficiencyParasite burdenHuman babesiosisBabesia microti infectionHigher antibody levelsMild clinical symptomsSevere B cell deficiencyB cell populationsT memory stem cellsMemory stem cellsPeak parasite burdenClinical immunityImmune controlImmunologic findingsNK cellsAntibody levelsClinical symptomsMicroti infectionB cellsPatientsSpecific antibodiesStem cellsBabesiosisImmunologyDeficiency
2019
Adaptive Immunity: Effector Functions, Regulation, and Vaccination
Kavathas P, Krause P, Ruddle N. Adaptive Immunity: Effector Functions, Regulation, and Vaccination. 2019, 75-95. DOI: 10.1007/978-3-030-25553-4_5.ChaptersAntigen-presenting cellsT cellsB cellsImmune responseInnate cellsEffector cellsInnate antigen-presenting cellsCD4 T helper cellsEffector T cellsB memory cellsT helper cellsSecondary lymphoid organsNaive T cellsBalanced immune responsePathogen-infected host cellsCD4 subsetCytokine milieuHelper cellsLymphoid organsEffector TPlasma cellsEffector functionsAdaptive immuneTypes of pathogensMacrophage responseOrganization and Cells of the Immune System
Kavathas P, Krause P, Ruddle N. Organization and Cells of the Immune System. 2019, 21-38. DOI: 10.1007/978-3-030-25553-4_2.ChaptersImmune cellsImmune systemLymphoid organsDifferent immune cell typesTertiary lymphoid organsInnate lymphoid cellsDifferent immune cellsSecondary lymphoid organsImmune cell typesLymphatic vesselsAdaptive immune systemHuman immune systemDendritic cellsBarrier immunityChronic inflammationUrinary tractSoluble mediatorsLymphoid cellsB cellsLymphoid systemMucosal surfacesChemokinesCytokinesOrgansCell types
2012
Cellular basis for clearance of the protozoan parasite Babesia microti in immunocompromised hosts (43.13)
Vannier E, Silver Z, Wilson C, Su J, Chiam J, Laurie S, Telford S, Gelfand J, Krause P, Wortis H. Cellular basis for clearance of the protozoan parasite Babesia microti in immunocompromised hosts (43.13). The Journal Of Immunology 2012, 188: 43.13-43.13. DOI: 10.4049/jimmunol.188.supp.43.13.Peer-Reviewed Original ResearchCD4-/- miceB cellsT cellsMild flu-like illnessBabesia microtiResolution of parasitemiaAbsence of CD4Flu-like illnessRag1-/- miceRole of complementB-cell lymphomaCourse of infectionPrimary etiologic agentMature B cellsCD4-CD8Specific IgGAnti-CD20Athymic miceCell lymphomaFc receptorsHealthy individualsCD4ParasitemiaEtiologic agentInfectious diseases