2018
Genomic Heterogeneity and the Small Renal Mass
Ueno D, Xie Z, Boeke M, Syed J, Nguyen KA, McGillivray P, Adeniran A, Humphrey P, Dancik GM, Kluger Y, Liu Z, Kluger H, Shuch B. Genomic Heterogeneity and the Small Renal Mass. Clinical Cancer Research 2018, 24: 4137-4144. PMID: 29760223, PMCID: PMC6125159, DOI: 10.1158/1078-0432.ccr-18-0214.Peer-Reviewed Original Research
2001
The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer
Vollmer R, Humphrey P. The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer. American Journal Of Clinical Pathology 2001, 116: 864-870. PMID: 11764075, DOI: 10.1309/7mq7-mwar-4w8a-r75f.Peer-Reviewed Original ResearchConceptsElevated PSA levelsEarly deathPSA levelsRadical prostatectomyProstate cancerPathology observationsGleason grade 5Overall good prognosisTime of prostatectomyPostoperative levelsPSA failureStudy patientsBetter prognosisProgressive tumorsPrognostic categoriesPercentage carcinomaProstatectomySubsequent outcomesLower hazardDeathSurgeryHigher hazardCancerMenPSA
2000
Renal Cell Carcinoma With Rhabdoid Features
Gökden N, Nappi O, Swanson P, Pfeifer J, Vollmer R, Wick M, Humphrey P. Renal Cell Carcinoma With Rhabdoid Features. The American Journal Of Surgical Pathology 2000, 24: 1329-1338. PMID: 11023094, DOI: 10.1097/00000478-200010000-00002.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaAdult renal cell carcinomaGlial fibrillary acidic proteinEpithelial membrane antigenNeuron-specific enolaseMuscle-specific actinSmooth muscle actinCases of RCCRhabdoid featuresCell carcinomaRhabdoid componentRhabdoid elementsRhabdoid tumorIncidence of RCCGrade 4 casesGrade 2 casesRadical nephrectomy specimensGrade I casesFibrillary acidic proteinGrade 3 casesPanel of antibodiesLarge epithelioid cellsIntracytoplasmic hyaline globulesHigh-stage carcinomasMajority of casesConcurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas?
Kaleem Z, Lind A, Humphrey P, Sueper R, Swanson P, Ritter J, Wick M. Concurrent Ki-67 and p53 Immunolabeling in Cutaneous Melanocytic Neoplasms: An Adjunct for Recognition of the Vertical Growth Phase in Malignant Melanomas? Modern Pathology 2000, 13: 217-222. PMID: 10757331, DOI: 10.1038/modpathol.3880040.Peer-Reviewed Original Research
1997
Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia
Reyes A, Swanson P, Carbone J, Humphrey P. Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia. The American Journal Of Surgical Pathology 1997, 21: 1215-1222. PMID: 9331295, DOI: 10.1097/00000478-199710000-00013.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaSignet ring cellsSmall cell carcinoma cellsProstatic intraepithelial neoplasiaProstate-specific antigenInvasive carcinomaIntraepithelial neoplasiaPrimary signet-ring cell carcinomaGrade prostatic intraepithelial neoplasiaSignet ring cell carcinomaCases of HGPINCarcinoma cellsNeuron-specific enolaseProstatic cell typesUnusual histologic typeSmall cell neuroendocrineGlandular epithelial cellsArchitectural growth patternIntraepithelial proliferationMucinous distensionCell typesMucinous featuresStrength of associationHistologic typeCell carcinomaCT of cystic renal masses: analysis of diagnostic performance and interobserver variation.
Siegel C, McFarland E, Brink J, Fisher A, Humphrey P, Heiken J. CT of cystic renal masses: analysis of diagnostic performance and interobserver variation. American Journal Of Roentgenology 1997, 169: 813-8. PMID: 9275902, DOI: 10.2214/ajr.169.3.9275902.Peer-Reviewed Original Research
1996
Repeat biopsy strategy in men with isolated prostatic intraepithelial neoplasia on prostate needle biopsy.
Shepherd D, Keetch D, Humphrey P, Smith D, Stahl D. Repeat biopsy strategy in men with isolated prostatic intraepithelial neoplasia on prostate needle biopsy. Journal Of Urology 1996, 156: 460-2; discussion 462-3. PMID: 8683703, DOI: 10.1097/00005392-199608000-00038.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleHumansMaleMiddle AgedProstatic Intraepithelial NeoplasiaProstatic NeoplasmsConceptsHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaIntraepithelial neoplasiaRepeat biopsyNeedle biopsyBiopsy techniqueSide of cancerProstate needle biopsyLocation of cancerInitial biopsySystematic biopsyMen 31Biopsy strategyBiopsyNeoplasiaCancerProstateQuadrant locationStrongest predictorPatientsMenSame sideMalignancyDiseaseRepeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle Biopsy
Shepherd D, Keetch D, Humphrey P, Smith D, Stahl D. Repeat Biopsy Strategy in Men with Isolated Prostatic Intraepithelial Neoplasia on Prostate Needle Biopsy. Journal Of Urology 1996, 156: 460-463. DOI: 10.1016/s0022-5347(01)65881-6.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleHumansMaleMiddle AgedProstatic Intraepithelial NeoplasiaProstatic NeoplasmsConceptsHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaIntraepithelial neoplasiaRepeat biopsyNeedle biopsyBiopsy techniqueSide of cancerProstate needle biopsyLocation of cancerPercent of casesInitial biopsySystematic biopsyMen 31Biopsy strategyBiopsyNeoplasiaCancerProstateQuadrant locationPatientsStrongest predictorMenSame sideMalignancy
1995
Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels
Nadler R, Humphrey P, Smith D, Catalona W, Ratliff T. Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels. Journal Of Urology 1995, 154: 407-413.. PMID: 7541857, DOI: 10.1097/00005392-199508000-00023.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overHumansMaleMiddle AgedMultivariate AnalysisProstate-Specific AntigenProstatic HyperplasiaProstatitisUltrasonographyConceptsHigh PSA groupMultiple negative biopsiesSerum PSA concentrationNegative biopsyProstate volumeRectal examinationPSA groupElevated serum prostate-specific antigen concentrationSerum prostate-specific antigen levelSerum prostate-specific antigen (PSA) concentrationElevated serum prostate-specific antigen (PSA) levelPSA concentrationProstate-specific antigen levelProstate-specific antigen concentrationSubclinical prostatic inflammationSuspicious rectal examinationDetectable prostate cancerSpecific antigen levelsDigital rectal examinationSpecific antigen concentrationBenign prostatic hyperplasiaEffects of inflammationProstatic inflammationPSA elevationAntigen levelsEffect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels
Nadler R, Humphrey P, Smith D, Catalona W, Ratliff T. Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels. Journal Of Urology 1995, 154: 407-413. DOI: 10.1016/s0022-5347(01)67064-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overHumansMaleMiddle AgedMultivariate AnalysisProstate-Specific AntigenProstatic HyperplasiaProstatitisUltrasonographyConceptsHigh PSA groupMultiple negative biopsiesSerum PSA concentrationNegative biopsyRectal examinationPSA groupElevated serum prostate-specific antigen concentrationSerum prostate-specific antigen levelSerum prostate-specific antigen (PSA) concentrationElevated serum prostate-specific antigen (PSA) levelPSA concentrationProstate-specific antigen levelProstate-specific antigen concentrationSubclinical prostatic inflammationSuspicious rectal examinationDetectable prostate cancerSpecific antigen levelsDigital rectal examinationSpecific antigen concentrationBenign prostatic hyperplasiaEffects of inflammationProstatic inflammationPSA elevationProstate volumeAntigen levelsMorphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate
Keetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Journal Of Urology 1995, 154: 347-351. DOI: 10.1016/s0022-5347(01)67044-7.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleFollow-Up StudiesHumansLogistic ModelsMaleMiddle AgedProstate-Specific AntigenProstatic NeoplasmsConceptsProstatic intraepithelial neoplasiaHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaSerum PSA concentrationRepeat biopsyIntraepithelial neoplasiaProstate needle biopsyProstate-specific antigenNeedle biopsyInitial biopsyProstate cancerNumber of fociElevated serum PSA concentrationInitial prostate needle biopsyPSA concentrationMen 50 yearsPredictors of cancerDigital rectal examinationInitial biopsy specimenCancer detection rateFinding of cancerSignificance of gradeClinical followupPSA densityPatient ageMorphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate
Keetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Journal Of Urology 1995, 154: 347-351.. PMID: 7541850, DOI: 10.1097/00005392-199508000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleFollow-Up StudiesHumansLogistic ModelsMaleMiddle AgedProstate-Specific AntigenProstatic NeoplasmsConceptsProstatic intraepithelial neoplasiaHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaSerum PSA concentrationRepeat biopsyIntraepithelial neoplasiaProstate needle biopsyProstate-specific antigenNeedle biopsyInitial biopsyProstate cancerNumber of fociElevated serum PSA concentrationInitial prostate needle biopsyPSA concentrationMen 50 yearsPredictors of cancerDigital rectal examinationInitial biopsy specimenCancer detection rateFinding of cancerSignificance of gradeClinical followupPSA densityPatient age
1994
Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors
Berchuck A, Kohler M, Hopkins M, Humphrey P, Robboy S, Rodriguez G, Soper J, Clarke-Pearson D, Bast R. Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors. Gynecologic Oncology 1994, 52: 232-236. PMID: 7508877, DOI: 10.1006/gyno.1994.1037.Peer-Reviewed Original ResearchConceptsEpithelial ovarian tumorsOverexpression of p53Borderline epithelial ovarian tumorsEpithelial ovarian cancerOvarian tumorsBorderline tumorsOvarian cancerEarly-stage borderline ovarian tumorsStage I/II casesBenign epithelial ovarian tumorsInvasive epithelial ovarian cancerBorderline ovarian tumorsBenign ovarian tumorsStage III casesAdvanced stage casesBenign tumorsMutant p53 proteinP53 tumor suppressor gene productIII casesStage casesTumorsII casesP53 proteinTumor suppressor gene productP53