1998
Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2. Journal Of Urology 1998, 160: 1935-1936. DOI: 10.1016/s0022-5347(01)62455-8.Peer-Reviewed Original ResearchInvasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2. Journal Of Urology 1998, 160: 1935-1936.. DOI: 10.1097/00005392-199811000-00095.Peer-Reviewed Original ResearchPseudohyperplastic Prostatic Adenocarcinoma
Humphrey P, Kaleem Z, Swanson P, Vollmer R. Pseudohyperplastic Prostatic Adenocarcinoma. The American Journal Of Surgical Pathology 1998, 22: 1239-1246. PMID: 9777986, DOI: 10.1097/00000478-199810000-00009.Peer-Reviewed Original ResearchConceptsCases of adenocarcinomaProstatic adenocarcinomaHyperplastic featuresNeedle biopsyProstate carcinoma growthUsual epithelial hyperplasiaProstatic needle biopsyLow Gleason scoreLow-grade carcinomaRadical prostatectomy specimensRadical prostatectomy tissueGleason pattern 2Cystic dilatationPathologic stagePrognostic implicationsTumor sizeGleason scoreHistologic gradePapillary infoldingsRadical prostatectomyUsual hyperplasiaHistologic variantsPrognostic informationProstatic carcinomaCarcinomatous fociProstatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens
Kaleem Z, Swanson P, Vollmer R, Humphrey P. Prostatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens. American Journal Of Clinical Pathology 1998, 109: 695-703. PMID: 9620026, DOI: 10.1093/ajcp/109.6.695.Peer-Reviewed Original ResearchConceptsAtrophic featuresProstatic adenocarcinomaRadical prostatectomy specimensProstatic carcinomaAtrophic carcinomaProliferation indexProstatectomy specimensCarcinoma volumeUsual prostatic adenocarcinomaInfiltrative growth patternMean proliferation indexKi-67 immunolabelingBiotin nick end labelingRadical prostatectomy casesProstatic adenocarcinoma casesGleason grade 3Nick end labelingAtrophic patternUntreated patientsAtrophic changesPathologic stagePrognostic implicationsGlandular atrophyHistologic gradeAdenocarcinoma casesInvasion of the bladder by transitional cell carcinoma
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the bladder by transitional cell carcinoma. Cancer 1998, 82: 715-723. PMID: 9477105, DOI: 10.1002/(sici)1097-0142(19980215)82:4<715::aid-cncr15>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, Transitional CellEpidermal Growth FactorHumansImmunoenzyme TechniquesKi-67 AntigenLogistic ModelsNeoplasm InvasivenessNeoplasm ProteinsNeoplasm StagingPrognosisProspective StudiesProto-Oncogene Proteins c-bcl-2Receptor, ErbB-2Tumor Suppressor Protein p53Urinary Bladder NeoplasmsConceptsC-erb BTransitional cell carcinomaEpidermal growth factor receptorGrade 3 tumorsHistologic gradeMIB-1Cell carcinomaBcl-2Prognostic informationMultivariate logistic regression modelGrade 2 tumorsLogistic regression modelsWorld Health OrganizationGrowth factor receptorCombination of markersPrognostic factorsClinical outcomesProspective studyImmunohistochemical stainingPathologic levelsProtective effectLevel of invasionGrade 2Multivariate analysisCarcinoma
1995
Relationship between serum prostate specific antigen, needle biopsy findings, and histopathologic features of prostatic carcinoma in radical prostatectomy tissues
Humphrey P, Baty J, Keetch D. Relationship between serum prostate specific antigen, needle biopsy findings, and histopathologic features of prostatic carcinoma in radical prostatectomy tissues. Cancer 1995, 75: 1842-1849. DOI: 10.1002/1097-0142(19950401)75:7+<1842::aid-cncr2820751614>3.0.co;2-2.Peer-Reviewed Original ResearchSerum prostate-specific antigenProstate-specific antigenPSA densityNeedle biopsy findingsPositive biopsy resultsHistologic gradeNeedle biopsyBiopsy findingsHistopathologic featuresTumor sizeBiopsy resultsProstate cancerPretreatment serum prostate-specific antigenSpecific antigenWhole glandAggressive prostate cancerPercentage of carcinomaRadical prostatectomy specimensRadical prostatectomy tissueWhole prostate glandBiopsy featuresPathologic stageDifferentiated tumorsProstatic carcinomaTumor grade
1993
Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma
Ibrahim S, Lightner V, Ventimiglia J, Ibrahim G, Walther P, Bigner D, Humphrey P. Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. Human Pathology 1993, 24: 982-989. PMID: 7504654, DOI: 10.1016/0046-8177(93)90112-t.Peer-Reviewed Original ResearchConceptsWestern blot analysisIntraepithelial neoplasiaCarcinoma cell linesProstatic hyperplasiaProstatic tissueBlot analysisAdult prostatic tissuesMetastatic prostatic carcinomaGrade of adenocarcinomaHuman prostatic carcinoma cell linesBone marrow samplesProstatic carcinoma cell linesHuman prostate tissueCell linesExpression of tenascinConnective tissue frameworkLymph nodesHistologic gradeProstatic carcinomaStromal alterationsTenascin immunoreactivityMarrow samplesStrong immunoreactivityStromal immunoreactivityProstate tissueComplete Histologic Serial Sectioning of a Prostate Gland with Adenocarcinoma
Humphrey P. Complete Histologic Serial Sectioning of a Prostate Gland with Adenocarcinoma. The American Journal Of Surgical Pathology 1993, 17: 468-472. PMID: 8470761, DOI: 10.1097/00000478-199305000-00005.Peer-Reviewed Original ResearchStratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels
Humphrey P, Frazier H, Vollmer R, Paulson D. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels. Cancer 1993, 71: 1821-1827. PMID: 7680602, DOI: 10.1002/1097-0142(19930301)71:5<1821::aid-cncr2820710517>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsPostoperative PSA levelPostoperative serum PSA levelsSerum PSA levelsRadical prostatectomy specimensIntraglandular tumor extentPSA levelsPathologic stageMargin positivityProstate-specific antigenHistologic gradeProstatectomy specimensResidual carcinomaPathologic featuresTumor extentSerum prostate-specific antigen levelPercentage carcinomaProstate-specific antigen levelExtension of carcinomaGleason histologic gradeOrgan-confined carcinomaLogistic regression analysisImportant morphologic parametersIntraglandular carcinomaAntigen levelsRadical prostatectomy
1991
Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma
Humphrey P, Walther P, Currin S, Vollmer R. Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma. The American Journal Of Surgical Pathology 1991, 15: 1165-1170. PMID: 1746683, DOI: 10.1097/00000478-199112000-00007.Peer-Reviewed Original ResearchConceptsHistologic gradeDNA ploidyTumor progressionTumor areaClinical stage B adenocarcinomaIntraglandular tumor extentStage B adenocarcinomaIndependent predictive factorsCox model analysisLikelihood of aneuploidyLogistic regression modelsB adenocarcinomaPredictive factorsTumor extensionProstatic carcinomaTumor extentProstatectomy specimensMultivariate analysisConcurrent useProgressionAdditional predictive abilityProstateImportant predictorRegression models
1990
Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens
Humphrey P, Vollmer R. Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens. Human Pathology 1990, 21: 799-804. PMID: 2387573, DOI: 10.1016/0046-8177(90)90048-a.Peer-Reviewed Original ResearchConceptsHistologic gradeTumor extentProstatectomy specimensTumor progressionPatient survivalProstatic carcinomaIntraglandular tumor extentExtent of tumorProportional hazards modelLogistic regression analysisSignificant prognosticatorPoor outcomeProstatic adenocarcinomaSurvival timeHazards modelProstatic tissueProstate glandEntire prostateProstate tissueConcurrent useTumorsCarcinomaProstateInterobserver agreement valuesProgression