Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos
Gruber P, Kubalak S, Chien K. Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos. Development 1998, 125: 4427-4438. PMID: 9778502, DOI: 10.1242/dev.125.22.4427.Peer-Reviewed Original ResearchConceptsCardiac chamber morphogenesisChamber morphogenesisMurine embryosChamber specificationMLC-2aOnset of cardiogenesisVentricular chamber maturationMuscle cell lineageWild-type embryosVentricular chamber morphogenesisWild-type backgroundMuscle cellsAtrial markersCritical signaling eventDistinct tissue typesChamber maturationMyosin light chain 2Ventricular muscle cellsVertebrate cardiogenesisLight chain 2Signaling eventsAtrial myosin light chain 2Mechanistic dissectionAlpha-myosin heavy chainCell lineages