High-Efficiency, Long-Term Cardiac Expression of Foreign Genes in Living Mouse Embryos and Neonates
Christensen G, Minamisawa S, Gruber P, Wang Y, Chien K. High-Efficiency, Long-Term Cardiac Expression of Foreign Genes in Living Mouse Embryos and Neonates. Circulation 2000, 101: 178-184. PMID: 10637206, DOI: 10.1161/01.cir.101.2.178.Peer-Reviewed Original ResearchConceptsMouse myocardiumDirect intracardiac injectionAdult mouse myocardiumCardiac gene transferNeonatal miceIntracardiac injectionInfected myocytesMicrosurgical approachFunctional assessmentGene transfer strategiesCardiac expressionVentricular cavityVivo gene transferNormal physiological functionCardiac ventriclesGene transferMurine heartGene expressionPattern of expressionMyocardiumRecombinant adenovirusGene ablationAdenovirus vectorLong-term foreign gene expressionCardiac wall