Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network
Liang Y, Lu Q, Li W, Zhang D, Zhang F, Zou Q, Chen L, Tong Y, Liu M, Wang S, Li W, Ren X, Xu P, Yang Z, Dong S, Zhang B, Huang Y, Li D, Wang H, Yu W. Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network. Nucleic Acids Research 2021, 49: 8556-8572. PMID: 34329471, PMCID: PMC8421228, DOI: 10.1093/nar/gkab626.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCarcinogenesisDNA MethylationEnhancer Elements, GeneticEpigenomicsFemaleGene Expression Regulation, NeoplasticGene SilencingHumansMicroRNAsPromoter Regions, GeneticReceptors, EstrogenReceptors, G-Protein-CoupledRegulatory Sequences, Nucleic AcidRNA, NeoplasmTumor Suppressor ProteinsConceptsTumor suppressor geneLowest expression of miRNABreast cancerLow expressionDysfunction of tumor suppressor genesLoss of function of tumor suppressor genesTriple negative breast cancer subtypeCancer developmentFunction of tumor suppressor genesMiR-339Inactivation of tumor suppressor genesClinical breast cancer treatmentTumor suppressor gene inactivationExpression of miRNAsReactivation of tumor suppressor genesBreast cancer subtypesBreast cancer cellsBreast cancer treatmentLuminal A/BPaired breast cancerAberrant histone modificationsGPER1 expressionEpigenetic abnormalitiesCancer subtypesSuppressor gene