Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker
Dong S, Li W, Wang L, Hu J, Song Y, Zhang B, Ren X, Ji S, Li J, Xu P, Liang Y, Chen G, Lou J, Yu W. Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker. Cancer Research 2019, 79: 6101-6112. PMID: 31575549, DOI: 10.1158/0008-5472.can-19-1019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBronchoalveolar Lavage FluidCell Line, TumorCpG IslandsDatasets as TopicDNA MethylationEarly Detection of CancerFemaleGene Expression Regulation, NeoplasticGenetic LociHistonesHumansLung NeoplasmsMaleMiddle AgedPromoter Regions, GeneticWhole Genome SequencingConceptsHistone-related genesWhole-genome DNA methylation analysisDNA methylation analysisHistone genesCancer Genome AtlasMethylation signaturesMethylation analysisGenesGenome AtlasPan-cancerBronchoalveolar lavage fluid samplesHypermethylationLavage fluid samplesEarly cancer diagnosisTCGA datasetPan-cancer biomarkerLung cancerTCGACancer-related deathsLung cancer cohortMethylationCancer cohortTumor typesTumorigenesisCancer diagnosis