Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks
Li J, Li Y, Li W, Luo H, Xi Y, Dong S, Gao M, Xu P, Zhang B, Liang Y, Zou Q, Hu X, Peng L, Zou D, Wang T, Yang H, Jiang C, Peng S, Wu F, Yu W. Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks. Genome Research 2019, 29: 270-280. PMID: 30670627, PMCID: PMC6360814, DOI: 10.1101/gr.240606.118.Peer-Reviewed Original ResearchConceptsWhole-genome bisulfite sequencingAberrant DNA methylationDNA methylationCell identityPredictor of gene expressionGenome-wide DNA methylationWhole-genome DNA methylationAberrant DNA methylation patternsDNA methylation patternsExpression of genes associated with immunityGenes associated with immunityAltering cell identityGene bodiesGC-richGenomic variationRepetitive regionsBisulfite sequencingMethylation patternsMethylation differencesGene expressionModulate expressionImmune surveillance networkLiver cancer developmentSequenceCancer development