2016
Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition
Zhao S, Bellone S, Lopez S, Thakral D, Schwab C, English DP, Black J, Cocco E, Choi J, Zammataro L, Predolini F, Bonazzoli E, Bi M, Buza N, Hui P, Wong S, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Facchetti F, Falchetti M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Mane S, Angioli R, Terranova C, Quick CM, Edraki B, Bilgüvar K, Lee M, Choi M, Stiegler AL, Boggon TJ, Schlessinger J, Lifton RP, Santin AD. Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 12238-12243. PMID: 27791010, PMCID: PMC5087050, DOI: 10.1073/pnas.1614120113.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinosarcomaClass I Phosphatidylinositol 3-KinasesDNA-Binding ProteinsEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHistonesHumansMiddle AgedMutationOvarian NeoplasmsPTEN PhosphohydrolaseTelomeraseTumor Suppressor Protein p53Uterine NeoplasmsConceptsEpithelial-mesenchymal transitionWhole-exome sequencingHistone gene clusterMutational landscapeStable transgenic expressionExcess of mutationsMultiregion whole-exome sequencingHistone genesEvolutionary historyPhylogenetic relationshipsGene clusterHistone H2AChromosome segmentsSeparate lineagesCancer genesGenetic landscapeUterine serous carcinoma cell linesTransgenic expressionGenesCarcinoma cell linesGene TP53Frequent amplificationFrequent deletionsChromosome 6pInvasive properties
2011
Gestational Trophoblastic Disease: General Aspects
Hui P. Gestational Trophoblastic Disease: General Aspects. Current Clinical Pathology 2011, 1-14. DOI: 10.1007/978-1-61779-394-3_1.Peer-Reviewed Original ResearchAncestral mammalsEndogenous versionsOviparous animalsEutherian mammalsTransient organFemale reproductionNutrient supplyMammalsFetomaternal organGenesMajor defining characteristicGas exchangeFlat cakeReproductionRound appearanceOrgansEggsExpressionPlacentaMaternal partDefining characteristicGeneral aspects
2005
Identification of Binding Sites of EVI1 in Mammalian Cells*
Yatsula B, Lin S, Read AJ, Poholek A, Yates K, Yue D, Hui P, Perkins AS. Identification of Binding Sites of EVI1 in Mammalian Cells*. Journal Of Biological Chemistry 2005, 280: 30712-30722. PMID: 16006653, DOI: 10.1074/jbc.m504293200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBinding SitesDNADNA-Binding ProteinsHerpes Simplex Virus Protein Vmw65HumansMDS1 and EVI1 Complex Locus ProteinMiceMolecular Sequence DataMutagenesis, Site-DirectedMutation, MissenseNIH 3T3 CellsOligonucleotide Array Sequence AnalysisProtein ConformationProto-OncogenesRecombinant Fusion ProteinsTranscription FactorsZinc FingersConceptsChromatin immunoprecipitationTarget genesN-terminal DNAPutative target genesVP16 fusion proteinTranscription start siteN-terminal domainGel shift assaysNIH 3T3 cellsZFPM2/FOG2Transcriptional activatorEndogenous genesMissense mutantsEVI1 bindsZinc fingerMammalian cellsStart siteShift assaysMutant formsFusion proteinTransactivation studiesSequence analysisGenesEVI1Binding sites
1998
Identification of candidate target genes for EVI-1, a zinc finger oncoprotein, using a novel selection strategy
Kim J, Hui P, Yue D, Aycock J, Leclerc C, Bjoring A, Perkins A. Identification of candidate target genes for EVI-1, a zinc finger oncoprotein, using a novel selection strategy. Oncogene 1998, 17: 1527-1538. PMID: 9794230, DOI: 10.1038/sj.onc.1202331.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsBase SequenceBinding SitesCalcium ChannelsDNA-Binding ProteinsDNA, ComplementaryEscherichia coliExonsGenomic LibraryHaploidyHumansInositol 1,4,5-Trisphosphate ReceptorsMDS1 and EVI1 Complex Locus ProteinMiceMolecular Sequence DataOncogene ProteinsProto-OncogenesReceptors, Cytoplasmic and NuclearRecombinant Fusion ProteinsSequence AlignmentTranscription FactorsTumor Cells, CulturedZinc FingersConceptsGenomic fragmentEvi-1Target genesZinc finger proteinHybrid selectionCandidate target genesTetracycline-regulated systemChimeric activatorFinger proteinHaploid genomeMouse cDNAMouse genomeGene sequencesMouse DNAFusion proteinTwo-step selectionGenesGenomeProteinCDNANovel selection strategyFragmentsHigh affinitySublibrariesITPR2