2023
KRAS mutation in primary ovarian serous borderline tumors correlates with tumor recurrence
McHenry A, Rottmann D, Buza N, Hui P. KRAS mutation in primary ovarian serous borderline tumors correlates with tumor recurrence. Virchows Archiv 2023, 483: 71-79. PMID: 37219599, DOI: 10.1007/s00428-023-03564-z.Peer-Reviewed Original ResearchConceptsOvarian serous borderline tumorsSerous borderline tumorsNon-invasive implantsDisease-free survivalKRAS mutationsTumor recurrenceExtraovarian implantsAdverse disease-free survivalWorse disease-free survivalHigher stage diseaseKRAS mutation testingHigher tumor stageWild-type KRASBRAF V600E mutationBRAF mutational analysisBorderline tumorsClinical outcomesHistological subtypesTumor stageBRAF mutationsUseful biomarkerInvasive implantsTumors correlatesV600E mutationMutational status
2017
KRAS mutation of extraovarian implants of serous borderline tumor: prognostic indicator for adverse clinical outcome
Zuo T, Wong S, Buza N, Hui P. KRAS mutation of extraovarian implants of serous borderline tumor: prognostic indicator for adverse clinical outcome. Modern Pathology 2017, 31: 350-357. PMID: 29027536, DOI: 10.1038/modpathol.2017.121.Peer-Reviewed Original ResearchConceptsAtypical proliferative serous tumorNon-invasive implantsDisease-specific survivalSerous borderline tumorsHigh recurrence rateWorse disease-specific survivalStage IIIC diseaseKRAS mutationsInvasive implantsBRAF V600E mutationBorderline tumorsSerous tumorsRecurrence rateIIIC diseaseClinical outcomesHistological subtypesPrognostic indicatorExtraovarian implantsV600E mutationLow-grade serous carcinomaUnfavorable disease-specific survivalAdverse clinical outcomesHigher stage diseaseSignificant prognostic indicatorBRAF mutation frequency
2016
Mucinous epithelial tumours arising from ovarian mature teratomas: a tissue genotyping study
Snir OL, Buza N, Hui P. Mucinous epithelial tumours arising from ovarian mature teratomas: a tissue genotyping study. Histopathology 2016, 69: 383-392. PMID: 26952875, DOI: 10.1111/his.12959.Peer-Reviewed Original ResearchConceptsOvarian mucinous tumorsMucinous borderline tumorsMucinous tumorsBorderline tumorsMucinous carcinomaAssociated teratomaPrimary ovarian mucinous tumorsOvarian mucinous borderline tumorMucinous epithelial tumorsOvarian mature teratomaGerm cell originShort tandem repeat polymorphic lociTissue genotypingMetastatic tumorsMature teratomaEpithelial tumorsTeratomatous componentsTumor originDiagnostic utilityMetastatic onesCell originTumorsTeratomaSomatic cellsPolymorphic loci
2010
Tumors of Fallopian Tube and Broad Ligament
Chhieng D, Hui P. Tumors of Fallopian Tube and Broad Ligament. Current Clinical Pathology 2010, 139-143. DOI: 10.1007/978-1-60761-164-6_9.Peer-Reviewed Original ResearchFallopian tubeBroad ligamentBenign tumorsBilateral nodular lesionsEctopic adrenal restsSalpingitis isthmica nodosaTubo-ovarian adhesionsSmooth muscle hypertrophyTumor-like conditionsCommon benign tumorRare benign tumorPeutz-Jeghers syndromeOvarian primaryChronic salpingitisEctopic pregnancyTubal pregnancyPelvic symptomsTubal mucosaAdrenal restsBorderline tumorsCystic alterationsPapillary lesionsNodular lesionsCommon findingMucinous metaplasiaTumors of Peritoneum
Chhieng D, Hui P. Tumors of Peritoneum. Current Clinical Pathology 2010, 193-207. DOI: 10.1007/978-1-60761-164-6_12.Peer-Reviewed Original ResearchPeritoneal serous carcinomaTumor-like conditionsTrophoblastic tumorSerous carcinomaPrimary peritoneal serous carcinomaIntermediate trophoblastic tumorGestational trophoblastic tumorsPrimary peritoneal tumorsFrequent differential diagnosisSecondary Mullerian systemExtraovarian primaryOvarian primaryParenchymal involvementMullerian systemBorderline tumorsPeritoneal tumorsSignificant morbidityDiffuse involvementMetastatic carcinomaGestational choriocarcinomaCommon tumorsMucinous lesionsReproductive yearsDifferential diagnosisDiagnostic criteria